Basic and clinical study of new diagnostic method for gastrointestinal cancer using the ratio of free DNA fragments in the serum
Basic and clinical study of new diagnostic method for gastrointestinal cancer using the ratio of free DNA fragments in the serum
批准号:
20591558
负责人:
OZAWA Soji
金额:
$3.16万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
The aim of this study was to analyze in the serum of nude mice that were implanted colorectal cancer cells and in the serum of colorectal cancer patients using Alu DNA sequences (Alu247 and Alu115) and to reveal whether Alu247/Alu115 ratio (Alu ratio) is related to outcome of treatments and to clinical-oncological factors. We concluded that the Alu ratio might be useful for predicting effects of chemotherapy and for discriminating between cancer and non-cancer. The Alu ratio was considered to have a higher discriminatory ability for diagnosing cancer than the CEA and CA19-9 tumor marker levels.
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Gene expression and effects of orally active derivatives off fluoropyrimidine on gastric and colorectal cancer
氟嘧啶口服活性衍生物对胃癌和结直肠癌的基因表达和影响
DOI:
--
发表时间:
2010
期刊:
Experimental and Therapeutic Medicine 1(1)
影响因子:
--
作者:
[Arakawa S, Ozawa S, Ooshima H, 他]
通讯作者:
他
胃癌と大腸癌における抗癌剤感受性関連遺伝子の発現と経口フッ化ピリミジン系抗癌剤の効果に関する検討
胃癌、结直肠癌抗癌药敏感性相关基因表达及口服氟嘧啶类抗癌药作用研究
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[荒川敏, 小澤壯治, 大島久徳, 他]
通讯作者:
他
血清遊離DNA断片比による大腸癌高感度診断法の検討
利用血清游离DNA片段比检验高灵敏结直肠癌诊断方法
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[荒川敏, 小澤壯治, 大島久徳, 他]
通讯作者:
他
Gene expression and effects of orally active derivatives off fluoropyrimidine on gastric and colorectal cancer.
氟嘧啶口服活性衍生物对胃癌和结直肠癌的基因表达和影响。
DOI:
--
发表时间:
2010
期刊:
Experimental and Therapeutic Medicine
影响因子:
2.7
作者:
[Arakawa S, et al]
通讯作者:
et al
血清遊離DNA断片比による消化器癌の悪性度診断の基礎的検討
基于血清游离DNA片段比值的胃肠道恶性肿瘤诊断基础研究
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[大島久徳, 小澤壯治, 荒川敏, 他]
通讯作者:
他
Study of vasohibin expression as a new biomarker in esophageal cancer and development of a new treatment targeting vasohibin
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批准号:17K10609
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
-
财政年份:2017
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负责人:OZAWA Soji
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依托单位:
Metabolome analysis of esophageal cancer tissues using capillary electrophoresis-time-of-flight mass spectrometry to search for new biomarker
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批准号:26461998
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
-
财政年份:2014
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负责人:OZAWA Soji
-
依托单位:
Basic and clinical research of circulating DNA fragments as a biomarker in gastroenterological cancer.
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批准号:23591907
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.49万
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财政年份:2011
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负责人:OZAWA Soji
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依托单位:
Analysis of new nucleic acid tumor marker in squamous cell carcinoma of the esophagus and establishment of diagnostic method of distant metastasis
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批准号:17591436
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2005
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负责人:OZAWA Soji
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依托单位:
Research of new recombinant anticancer drug against epidermal growth factor receptor as a molecular target
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批准号:13671338
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2001
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负责人:OZAWA Soji
-
依托单位:
Research of recombinant human RNase fused protein on angiogenesis and tumor growth
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批准号:11671272
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.5万
-
财政年份:1999
-
负责人:OZAWA Soji
-
依托单位:
Basic research of target the rapy of esophageal cancer using VEGF which is fused with biological active cytotoxic agents.
-
批准号:09671336
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.05万
-
财政年份:1997
-
负责人:OZAWA Soji
-
依托单位:
海外基金