The effects of adiponectin on lung cancer and lung disease

脂联素对肺癌和肺部疾病的影响

• 批准号: 20591674
• 负责人: TSUCHIYA Tomoshi
• 金额: $ 3万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591674/
• 关键词: アディポネクチン; リポポリサッカライド; 小胞体ストレス; 肺気腫; 肺癌; マイクロアレイ

In order to find out the effect of adiponectin on lung cancer and lung disease, we made elastase inhalation model, VEGF receptor blocker model, and LPS administration model. However obvious inhivitive effects were not observed. In the subcutaneous lung cancer cell injection model, the regular diet group of Tg mice showed increase tumor size and weight. Because the size of adipocytes were small and mRNA expressions of p21 and p16 and protein expressions of p21 and p53 were suppressed in adipose tissue of Tg mice, we presume the tissues of Tg mice are kept homeostasis in "young", which might induce cancer growth in adipose tissue.

为了了解脂联素在肺癌和肺部疾病中的作用，我们制作了弹性酶吸入模型、血管内皮生长因子受体阻滞剂模型和脂多糖给药模型。但未观察到明显的抑制作用。在皮下注射肺癌细胞模型中，常规饮食组小鼠的肿瘤体积和重量均有增加。由于转基因小鼠脂肪细胞体积较小，其脂肪组织中p21和p16mRNA的表达以及p21和p53蛋白的表达均受到抑制，因此推测转基因小鼠的脂肪组织在幼年时期维持着动态平衡，这可能是导致脂肪组织中肿瘤生长的原因。

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Overexpression of adiponectin is in involved in suppression of cell cycle regulators/senescence-related signals in adipose tissue

脂联素的过度表达参与抑制脂肪组织中的细胞周期调节因子/衰老相关信号

• 发表时间: 2011
• 作者: Shoji T;Bando T;Fujinaga T;Okubo K;Yukawa N;Mimori T;Date H.;Ryotaro Kamohara
• 通讯作者: Ryotaro Kamohara

Overexpression of regulators/ senescence-related signals in adipose tissue

脂肪组织中调节因子/衰老相关信号的过度表达

• 发表时间: 2011
• 作者: 蒲原涼太郎;下川功
• 通讯作者: 下川功