The effects of adiponectin on lung cancer and lung disease

为了了解脂联素对肺癌和肺部疾病的影响，我们制作了弹性蛋白酶吸入模型、VEGF受体阻滞剂模型和LPS给药模型。但未观察到明显的抑制作用。在皮下肺癌细胞注射模型中，正常饮食组Tg小鼠肿瘤体积增大，体重增加。由于Tg小鼠脂肪细胞体积小，且脂肪组织中p21、p16 mRNA表达和p21、p53蛋白表达受到抑制，我们推测Tg小鼠的组织在“年轻”时保持稳态，这可能导致脂肪组织癌变。

In order to find out the effect of adiponectin on lung cancer and lung disease, we made elastase inhalation model, VEGF receptor blocker model, and LPS administration model. However obvious inhivitive effects were not observed. In the subcutaneous lung cancer cell injection model, the regular diet group of Tg mice showed increase tumor size and weight. Because the size of adipocytes were small and mRNA expressions of p21 and p16 and protein expressions of p21 and p53 were suppressed in adipose tissue of Tg mice, we presume the tissues of Tg mice are kept homeostasis in "young", which might induce cancer growth in adipose tissue.