The role of cancer-host interaction in the invasion of lung adenocarcinoma

癌症-宿主相互作用在肺腺癌侵袭中的作用

• 批准号: 20591670
• 负责人: MANIWA Yoshimasa
• 金额: $ 2.91万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591670/
• 关键词: 呼吸器外科学; 肺癌; 浸潤; 癌宿主相互作用; 線維芽細; 線維芽細胞

A total of 63 surgically resected primary pulmonary adenocarcinoma tissues were investigated by immunohistochemistry for the expression of Necl-5. The overexpression of Necl-5 by cancer cells was significantly associated with lymph node metastasis, TNM staging and the bronchioloalveolar carcinoma ratio of tumors. Furthermore, the disease-free survival rate in patients with positive Necl-5 overexpression was significantly lower than that in patients with negative Necl-5 overexpression. These results indicate that Necl-5 plays a role in mediating tumor cell invasion and that the overexpression of Necl-5 in cancer cells has clinical significance for prognostic evaluation of patients with primary pulmonary adenocarcinoma.

应用免疫组织化学方法检测63例手术切除的原发性肺腺癌组织中NECL-5的表达。癌细胞Necl-5的过表达与肿瘤的淋巴结转移、TNM分期及细支气管肺泡癌的比例显著相关。此外，Necl-5过表达阳性患者的无瘤生存率显著低于Necl-5过表达阴性患者。提示NCEL-5在介导肿瘤细胞侵袭中起重要作用，肿瘤细胞中NCEL-5的过表达对评估原发性肺腺癌患者的预后有临床意义。

项目成果

The optimal timing to resect pulmonary metastasis

• DOI: 10.1016/j.ejcts.2008.03.002
• 发表时间: 2008-06-01
• 期刊: EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
• 影响因子: 3.4
• 作者: Tanaka, Yugo;Maniwa, Yoshimasa;Okita, Yutaka
• 通讯作者: Okita, Yutaka

The cytological characteristics of small cell change of dysplasia in small hepatic nodules

• DOI: 10.3892/or_00000754
• 发表时间: 2010-05-01
• 期刊: ONCOLOGY REPORTS
• 影响因子: 4.2
• 作者: Chang, Okki;Yano, Yoshihiko;Hayashi, Yoshitake
• 通讯作者: Hayashi, Yoshitake

Effective chemotherapy based on chemosensitivity test for malignant pleurnl mesothelioma

基于化疗敏感性试验的恶性胸膜间皮瘤的有效化疗

• 发表时间: 2008
• 期刊: Ann Thorac Cardiovasc Sure 14
• 作者: Maniwa Y;et al
• 通讯作者: et al

Non-synonymous SNPs in DNA damage repair pathways and lung cancer risk.

DNA 损伤修复途径和肺癌风险中的非同义 SNP。

• 发表时间: 2010
• 期刊: Cancer 116
• 作者: Tanaka Y;Maniwa Y;Bermudez VP;Doi T;Nishio W;Ohbayashi C;Okita Y;Hurwitz J;Hayashi Y;Yoshimura M.
• 通讯作者: Yoshimura M.

Non-synonymous SNPs in DNA damage repair pathways and lung cancer risk

DNA损伤修复途径和肺癌风险中的非同义SNP

• 发表时间: 2010
• 期刊: Cancer
• 影响因子: 6.2
• 作者: Maniwa Y.;et al.
• 通讯作者: et al.