The role of cancer-host interaction in the invasion of lung adenocarcinoma

采用免疫组化方法检测63例手术切除的原发性肺腺癌组织中Necl-5的表达。癌细胞Necl-5过表达与淋巴结转移、TNM分期及细支气管肺泡癌发生率显著相关。此外，Necl-5过表达阳性患者的无病生存率显著低于Necl-5过表达阴性患者。这些结果表明，Necl-5在介导肿瘤细胞侵袭中起作用，并且Necl-5在癌细胞中的过表达对于原发性肺腺癌患者的预后评估具有临床意义。

A total of 63 surgically resected primary pulmonary adenocarcinoma tissues were investigated by immunohistochemistry for the expression of Necl-5. The overexpression of Necl-5 by cancer cells was significantly associated with lymph node metastasis, TNM staging and the bronchioloalveolar carcinoma ratio of tumors. Furthermore, the disease-free survival rate in patients with positive Necl-5 overexpression was significantly lower than that in patients with negative Necl-5 overexpression. These results indicate that Necl-5 plays a role in mediating tumor cell invasion and that the overexpression of Necl-5 in cancer cells has clinical significance for prognostic evaluation of patients with primary pulmonary adenocarcinoma.