Analysis of Benefit of carotid endarterectomy by mathematical model

颈动脉内膜剥脱术疗效数学模型分析

• 批准号: 20591682
• 负责人: YOSHIMOTO Yuhei
• 金额: $ 2.91万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591682/
• 关键词: 頚動脈内膜剥離術; マルコフモデル

We constructed a Markov model to evaluate effectiveness of carotid endaterectomy (CEA). In modeling four health states, probabilities of transition to another state were estimated using data from major randomized control trials. CEA for severe carotid stenosis would consistently and significantly benefit patients with recent symptoms. However, surgery for asymptomatic stenosis appears justified only in carefully selected conditions : low treatment risks for relatively young individuals without any comorbidities.

我们建立了一个马尔可夫模型来评估颈动脉尾膜切除术（CEA）的有效性。在对四种健康状态建模时，使用来自主要随机对照试验的数据估计了过渡到另一状态的概率。CEA治疗严重颈动脉狭窄对近期出现症状的患者有持续且显著的益处。然而，手术治疗无症状狭窄似乎只有在精心选择的条件下才合理：相对年轻的个体治疗风险低，没有任何合并症。

项目成果

Clinicopathological feature of pilomyxoid astrocytoma : three case reports.

毛粘液样星形细胞瘤的临床病理特征：三例报告。

• 发表时间: 2010
• 期刊: Neuropathology (Epub ahead of print)
• 作者: Nagaishi M;Yokoo H;Hirato J;Yoshimoto Y;Nakazato Y
• 通讯作者: Nakazato Y

SIP2 receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN.

SIP2 受体通过独立于 PTEN 的 Rho 信号通路介导神经胶质瘤细胞迁移的抑制。

• 发表时间: 2008
• 期刊: Biochem Biophys Res Com 366
• 作者: Malchinkhuu E;Sato K;Maehama T;Mogi C;Tomura H;Ishiuchi S;Yoshimoto Y;Kurose H;Okajima F
• 通讯作者: Okajima F

Diffuse pachymeningeal hyperintensity and subdural effusion/hematoma detected by fluid-attenuated inversion recovery MR Imaging in patients with spontaneous intracranial hypertension.

通过液体衰减反转恢复磁共振成像检测自发性颅内高压患者的弥漫性硬脑膜高信号和硬膜下积液/血肿。

• 发表时间: 2008
• 期刊: AJNR 29
• 作者: Tosaka M;Sato N;Fujimaki H;Tanaka Y;Kagoshima K;Takahashi A;Saito N;Yoshimoto Y
• 通讯作者: Yoshimoto Y

Constitutive Reactive Oxygen Species Generation from Autophagosome/Lysosome in Neuronal Oxidative Toxicity

• DOI: 10.1074/jbc.m109.053058
• 发表时间: 2010-01-01
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Kubota, Chisato;Torii, Seiji;Takeuchi, Toshiyuki
• 通讯作者: Takeuchi, Toshiyuki

Epileptogenic ganglioglioma with hypermetabolism on positron emission tomography with Fluorine-18 Fluorodeoxyglucose.

使用氟 18 氟脱氧葡萄糖进行正电子发射断层扫描，发现致癫痫性神经节胶质瘤代谢亢进。

• 发表时间: 2010
• 期刊: Epilepsy and Seizure 3
• 作者: Ibe Y;Takahashi A;Ishiuchi S;Hirato M;Yoshimoto Y;Yuhara Y;Sasaki A
• 通讯作者: Sasaki A