Treatment using bisphosphonate for malignant bone and soft tissue tumors

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The lower dose of third generation bisphosphonates (BPs) significantly prevented lung metastasis for the in vivo effects of BPs, although the higher dose of BPs was required to inhibit the growth of osteosarcoma cells at the primary site. In addition, BPs inhibited the production of vascular endothelial growth factor and reduced the migration, adhesion, and invasiveness of osteosarcoma cells in vitro. Combinationtherapy using BPs and radiation augmented the antitumor effects. From the results ofantitumor effects of BPs against fibrosarcoma cells, BPs arrested the cell cycle in the S phases, inhibited cell proliferation, and induced the apoptosis of their cells. Moreover, BPs augmented the effect of antitumor agents when administered concurrently with them in human fibrosarcoma cells.