Treatment using bisphosphonate for malignant bone and soft tissue tumors

双膦酸盐治疗恶性骨和软组织肿瘤

• 批准号: 20591764
• 负责人: MURATA Hiroaki
• 金额: $ 2.91万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591764/
• 关键词: 悪性骨腫瘍; 悪性軟部腫瘍; ビスホスフォネート; 癌; 悪性軟部腫

The lower dose of third generation bisphosphonates (BPs) significantly prevented lung metastasis for the in vivo effects of BPs, although the higher dose of BPs was required to inhibit the growth of osteosarcoma cells at the primary site. In addition, BPs inhibited the production of vascular endothelial growth factor and reduced the migration, adhesion, and invasiveness of osteosarcoma cells in vitro. Combinationtherapy using BPs and radiation augmented the antitumor effects. From the results ofantitumor effects of BPs against fibrosarcoma cells, BPs arrested the cell cycle in the S phases, inhibited cell proliferation, and induced the apoptosis of their cells. Moreover, BPs augmented the effect of antitumor agents when administered concurrently with them in human fibrosarcoma cells.

低剂量的第三代双膦酸盐（bp）显著阻止了bp体内效应的肺转移，尽管高剂量的bp需要在原发部位抑制骨肉瘤细胞的生长。此外，bp抑制血管内皮生长因子的产生，降低骨肉瘤细胞在体外的迁移、粘附和侵袭性。bp联合放疗增强了抗肿瘤效果。从bp对纤维肉瘤细胞的抗肿瘤作用来看，bp阻滞细胞周期于S期，抑制细胞增殖，诱导细胞凋亡。此外，bp在人纤维肉瘤细胞中与抗肿瘤药物同时使用时，可以增强抗肿瘤药物的作用。

项目成果

骨軟部肉腫細胞株に対する第3世代Bisphosphonate 含有ハイドロキシアパタイトの抗腫瘍効果の検討

第三代双膦酸盐羟基磷灰石对骨和软组织肉瘤细胞系的抗肿瘤作用研究

• 发表时间: 2010
• 作者: 小藤和孝;村田博昭;坂部智哉;劉和輝;松井隆明;堀江直行;澤井泰志;芦原英司;伏木信次;前川平;久保俊一
• 通讯作者: 久保俊一

Combined effects of bisphosphonate and radiation on osteosarcoma cells

双膦酸盐和放射对骨肉瘤细胞的联合作用

• 发表时间: 2010
• 期刊: Anticancer Res
• 影响因子: 2
• 作者: Ryu K;Murata H;et al.
• 通讯作者: et al.

The third-generation bisphosphonate inhibits tumor growth and lung metastasis in murine osteosarcoma cells.

第三代双膦酸盐抑制小鼠骨肉瘤细胞的肿瘤生长和肺转移。

• 发表时间: 2009
• 作者: 村田博昭;小藤和孝;堀江直行;坂部智哉;松井隆明;伏木信次;木村晋也,前川平;久保俊一
• 通讯作者: 久保俊一

Clinically relevant dose of zoledronic acid inhibits spontaneous lung metastasis in a murine osteosarcoma model

• DOI: 10.1016/j.canlet.2008.09.026
• 发表时间: 2009-02-18
• 期刊: CANCER LETTERS
• 影响因子: 9.7
• 作者: Koto, Kazutaka;Horie, Naoyuki;Kubo, Toshikazu
• 通讯作者: Kubo, Toshikazu

Combined effects of a third-generation bisphosphonate and radiation against murine osteosarcoma.

第三代双膦酸盐和放射对小鼠骨肉瘤的联合作用。

• 发表时间: 2010
• 作者: 村田博昭;劉和輝;小藤和孝;堀江直行;小藤和孝;村田博昭;坂部智哉;劉和輝;西垣泰典;松井隆明;坂部智哉;西垣泰典;久保俊一
• 通讯作者: 久保俊一