Analysis of the mechanism of cartilage calcification using the spontaneously cartilage calcification insufficient rat

自发性软骨钙化不足的大鼠(CCI大鼠，Spraogue-Dawley品系的突变)出现侏儒症，伴随着四肢和全身长度的缩短。CCI大鼠以全身性软骨骨化缺失为特征，软骨内骨化缺失。CCI大鼠生长软骨钙化被认为是延迟的。在CCI大鼠生长板中，FGF18mRNA的表达水平明显升高，从而抑制了软骨钙化。在未来，我们打算阐明CCI大鼠软骨钙化不足的机制，并利用该动物来阐明软骨钙化的机制。

Rats with spontaneous cartilage calcification insufficiency (CCI rat, mutant of the Sprague-Dawley strain) develop dwarfism accompanied by the shortness of all 4 limbs and the overall body length. CCI rats are characterized by systemic ossification deficiency of cartilage, and it was revealed that deficient endochondral ossification is present. The growth cartilage calcification was considered to be delayed in CCI rats. In the growth plate of the CCI rats, the expression level of FGF18 mRNA was markedly high, and resulting inhibits cartilage calcification. In the future, we intend to clarify the mechanism of cartilage calcification insufficiency in CCI rats, and use this animal to elucidate the mechanism of cartilage calcification.