Assessing the severity of patients in therapeutic hypothermia for brain -ESR study-

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We focused on the free radicals which play an important role in brain cell damage especially in ischemia-reperfusion injury, and demonstrated that some antioxidants which can scavenge the free radicals had neuroprotective efficacy. In addition, we tried to observe the free radical dynamics with ESR device. On the other hand, therapeutic hypothermia is one of the worldwide medical treatments for protecting brain tissues in brain injury and cardiac surgery with heart-lung machine. We established the animal model of the hypothermia, which can be helpful for study using therapeutic hypothermia.