Assessing the severity of patients in therapeutic hypothermia for brain -ESR study-

评估大脑低温治疗患者的严重程度-ESR研究-

• 批准号: 20591808
• 负责人: SHINGU Chihiro
• 金额: $ 2.91万
• 依托单位: Oita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591808/
• 关键词: 全脳虚血; フリーラジカル; 電子スピン共鳴; 脳低体温療法

We focused on the free radicals which play an important role in brain cell damage especially in ischemia-reperfusion injury, and demonstrated that some antioxidants which can scavenge the free radicals had neuroprotective efficacy. In addition, we tried to observe the free radical dynamics with ESR device. On the other hand, therapeutic hypothermia is one of the worldwide medical treatments for protecting brain tissues in brain injury and cardiac surgery with heart-lung machine. We established the animal model of the hypothermia, which can be helpful for study using therapeutic hypothermia.

本文着重探讨了自由基在脑细胞损伤尤其是缺血再灌注损伤中的重要作用，并证明了一些能抑制自由基的抗氧化剂具有神经保护作用。此外，我们还尝试用ESR装置观察自由基动力学。另一方面，治疗性低温是目前世界范围内脑损伤和心肺机心脏手术中脑组织保护的医学治疗方法之一。本实验建立了低温动物模型，为低温治疗的研究奠定了基础。

项目成果

An Electron Spin Resonance Study for Real-time Detection of Ascorbyl Free Radicals After Addition of Dimethyl Sulfoxide in Murine Hippocampus or Plasma During Kainic Acid-Induced Seizures

• DOI: 10.1007/s11064-010-0148-9
• 发表时间: 2010-07-01
• 期刊: NEUROCHEMICAL RESEARCH
• 影响因子: 4.4
• 作者: Matsumoto, Shigekiyo;Shingu, Chihiro;Yokoi, Isao
• 通讯作者: Yokoi, Isao

The impact of oxidative stress levels on the clinical effectiveness of sivelestat in treating acute lung injury : an electron spin study.

氧化应激水平对西维来司他治疗急性肺损伤临床疗效的影响：一项电子自旋研究。

• 发表时间: 2010
• 期刊: Journal of Trauma 68
• 作者: Matsumoto S;Shingu C;Koga H;Hidaka S;Goto K;Hagiwara S;Iwasaka H;Noguchi T;Yokoi I.
• 通讯作者: Yokoi I.

The Impact of Oxidative Stress Levels on the Clinical Effectiveness of Sivelestat in Treating Acute Lung Injury: An Electron Spin Resonance Study

• DOI: 10.1097/ta.0b013e3181bb80d4
• 发表时间: 2010-04-01
• 期刊: JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
• 作者: Matsumoto, Shigekiyo;Shingu, Chihiro;Yokoi, Isao
• 通讯作者: Yokoi, Isao