Role of lipoxin as an inhibitory mediator in upper airway inflammation

脂氧素作为抑制介质在上呼吸道炎症中的作用

• 批准号: 20591999
• 负责人: SHIMIZU Takeshi
• 金额: $ 3万
• 依托单位: Shiga University of Medical Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591999/
• 关键词: 鼻科学; リポキシン; 慢性副鼻腔炎; 好酸球性副鼻腔炎; 鼻茸; アレルギー性鼻炎; IL-8; リポキシン受容体; 鼻粘膜; VEGF; プロスタグランディンE2; TNFα

To elucidate the inhibitory role of lipoxin A4 in upper airway inflammation, we examined the concentration of lipoxin A4 in nasal secretion, and tissue localization of ALX/FPRL-1 receptor in nasal mucosa. In vitro effects of lipoxin A4 on IL-8 secretion from cultured human airway epithelial cells were also examined.Significant concentrations of lipoxin A4 were found in nasal secretion from patients with allergic rhinitis and chronic rhinosinusitis. ALX/FPRL-1 receptor was detected in epithelial cells, submucosal gland cells and infiltrating cells in nasal mucosa. Increased expression of ALX/FPRL-1 receptor mRNA was found in nasal polyp, compared with nasal mucosa of inferior turbinate. Lipoxin A4 significantly inhibited TNF-alpha-induced IL-8 secretion from cultured human normal bronchial epithelial cells.These results indicate that lipoxin A4 may be an important inhibitory mediator in the pathogenesis of upper airway inflammation.

为了阐明脂氧蛋白A4在上部气道炎症中的抑制作用，我们检查了脂肪毒素A4在鼻分泌中的浓度，以及在鼻粘膜中ALX/FPRL-1受体的组织定位。还检查了脂毒素A4对培养的人气道上皮细胞IL-8分泌的IL-8分泌的体外作用。在患有过敏性鼻炎和慢性鼻鼻炎的患者的鼻分泌中发现了脂氧蛋白A4的显着浓度。在上皮细胞，粘膜下腺细胞和鼻粘膜浸润细胞中检测到ALX/FPRL-1受体。与下鼻甲的鼻粘膜相比，在鼻息中发现了ALX/FPRL-1受体mRNA的表达增加。脂氧蛋白A4显着抑制了TNFα诱导的人类正常支气管上皮细胞的IL-8分泌。这些结果表明，脂氧蛋白A4可能是上空炎症发病机理中重要的抑制介质。

项目成果

Prostaglandin E2 receptor agonists inhibit antigen-induced mucus production and eosinophil infiltration in rat nasal epithelium.

前列腺素 E2 受体激动剂抑制大鼠鼻上皮中抗原诱导的粘液产生和嗜酸性粒细胞浸润。

• 发表时间: 2008
• 作者: Shimizu T;Hattori R;Shimizu S;Majima Y
• 通讯作者: Majima Y

Role of prostaglandin E2 as a protective mediator for airway inflammation

前列腺素 E2 作为气道炎症保护介质的作用

• 发表时间: 2008
• 作者: Yoshida;T.;Sugiura;M.;Naganawa;S.;Teranishi;M.;Nakata;S.;Nakashima;T.;Shimizu T
• 通讯作者: Shimizu T

Prostaglandin E2 receptor EP2, EP3, and EP4 agonists inhibits antigen-induced mucus hypersecretion in the nasal epithelium of sensitized rats.

前列腺素 E2 受体 EP2、EP3 和 EP4 激动剂可抑制致敏大鼠鼻上皮中抗原诱导的粘液分泌过多。

• 发表时间: 2009
• 期刊: Ann Otol Rhinol Laryngol 118
• 作者: Hattori R;Shimizu S;Majima Y;Shimizu T
• 通讯作者: Shimizu T

上気道炎症におけるリポキシンの役割

脂氧素在上呼吸道炎症中的作用

• 期刊: 耳鼻免疫アレルギー(JJIAO) 印刷中
• 作者: 清水志乃;星恵理子;神前英明;清水猛史
• 通讯作者: 清水猛史

Prostaglandin E2 receptor (EP)agonists inhibit antigen-Induced mucus production and eosinophil infiltration in ratnasal epithelium

前列腺素 E2 受体 (EP) 激动剂抑制抗原诱导的大鼠鼻上皮粘液产生和嗜酸性粒细胞浸润

• 发表时间: 2008
• 作者: Shimizu T;Hattori R Shimizu S;Majima Y
• 通讯作者: Majima Y