Role of lipoxin as an inhibitory mediator in upper airway inflammation

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To elucidate the inhibitory role of lipoxin A4 in upper airway inflammation, we examined the concentration of lipoxin A4 in nasal secretion, and tissue localization of ALX/FPRL-1 receptor in nasal mucosa. In vitro effects of lipoxin A4 on IL-8 secretion from cultured human airway epithelial cells were also examined.Significant concentrations of lipoxin A4 were found in nasal secretion from patients with allergic rhinitis and chronic rhinosinusitis. ALX/FPRL-1 receptor was detected in epithelial cells, submucosal gland cells and infiltrating cells in nasal mucosa. Increased expression of ALX/FPRL-1 receptor mRNA was found in nasal polyp, compared with nasal mucosa of inferior turbinate. Lipoxin A4 significantly inhibited TNF-alpha-induced IL-8 secretion from cultured human normal bronchial epithelial cells.These results indicate that lipoxin A4 may be an important inhibitory mediator in the pathogenesis of upper airway inflammation.