Study of Shiga toxin productions us ing in vivo analysis
Study of Shiga toxin productions us ing in vivo analysis
批准号:
21590478
负责人:
SHIMIZU Takeshi
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
A novel chromosome-plasmid hybrid bioluminescent reporter system (C-P reporter system) utilizing Photorhabdus luminescens luxCDABE genes has been constructed to monitor the expression of Shiga toxin 1 (Stx1) and Shiga toxin 2 (Stx2) in enterohaemorrhagic Escherichia coli (EHEC) in real time. Using these reporter strains, we examined the profiles of Stx1 and Stx2 expression in EHEC. We found that production of both Stx1 and Stx2 in EHEC was enhanced upon contact with intestinal epithelial cells and within macrophages.
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NO biosensor plasmid for investigating NO levels within macrophages during bacterial infection
NO 生物传感器质粒用于研究细菌感染期间巨噬细胞内的 NO 水平
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[清水健, 津々木博康, 野田公俊]
通讯作者:
野田公俊
Recombinant Shiga toxin B subunit can induce neutralizing IgY antibody
重组志贺毒素B亚基可诱导中和IgY抗体
DOI:
--
发表时间:
2012
期刊:
Biol. Pharm. Bull
影响因子:
--
作者:
[Neri P, Tokoro S, Sugiyama T, Umeda K, Shimizu T, Tsuji T, Kodama Y, Mori H]
通讯作者:
Mori H
Effect of phage-inducing agent on the number of Stx2-expressed cells in Shiga toxin-producing Escherichia coli
噬菌体诱导剂对产志贺毒素大肠杆菌中Stx2表达细胞数量的影响
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[清水健, 野田公俊]
通讯作者:
野田公俊
Adherent effects of enterohemorrahgic Escherichia coli to human intestinal epithelial cells on its Shiga toxins production
肠出血性大肠杆菌对人肠上皮细胞的粘附对其志贺毒素产生的影响
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Ito A, Matsuo J, Nakamura S, Hayashi Y, Yoshoda A, Yoshoda M, Takahashi K, Yamaguchi H, Takeshi Shimizu Masatoshi Noda]
通讯作者:
Takeshi Shimizu Masatoshi Noda
清水健腸管出血性大腸菌の産生する志賀毒素について
关于清水健肠出血性大肠杆菌产生的志贺毒素
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Ishida K, Kobayashi M, Matsuo J, Nakamura S, Yamaguchi H, 清水健]
通讯作者:
清水健
共 19 条
Effects of excercise continuity using motion games for groups who don't have exercise habits
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批准号:25750344
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.5万
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财政年份:2013
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负责人:SHIMIZU Takeshi
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依托单位:
Molecular mechanisms that function in oligodendrocyte myelination
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批准号:24890291
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项目类别:Grant-in-Aid for Research Activity Start-up
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资助金额:$1.91万
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财政年份:2012
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负责人:SHIMIZU Takeshi
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依托单位:
Role of lipoxin as an inhibitory mediator in upper airway inflammation
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批准号:20591999
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2008
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负责人:SHIMIZU Takeshi
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依托单位:
Analysis of secretion system of virulence factor in gram-negative bacteria
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批准号:19590440
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
-
财政年份:2007
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负责人:SHIMIZU Takeshi
-
依托单位:
Study on the virulence factors of enterohemorrhagic Escherichia coli
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批准号:17590382
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
-
财政年份:2005
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负责人:SHIMIZU Takeshi
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依托单位:
Synthesis and Biological Evaluation of Antifungal Antibiotics, Spirofungin A and B
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批准号:16590026
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
-
财政年份:2004
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负责人:SHIMIZU Takeshi
-
依托单位:
Prostaglandin E_2 inhibits airway inflammation
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批准号:15591804
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.05万
-
财政年份:2003
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负责人:SHIMIZU Takeshi
-
依托单位:
Studies for Structure-Activities Relationships of Reveromycin A : An Inhibitor of Eukaryotic Cell Growth
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批准号:14572104
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.92万
-
财政年份:2002
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负责人:SHIMIZU Takeshi
-
依托单位:
Synthetic Studies of Reveromycin A : An Inhibitor of Eukaryotic Cell Growth
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批准号:12672082
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.18万
-
财政年份:2000
-
负责人:SHIMIZU Takeshi
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依托单位:
DEVELOPMENT OF USEFUL REACTIONS USING THE NOVEL LEAVING GROUP, MONOCHLATE
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批准号:10672015
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
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财政年份:1998
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负责人:SHIMIZU Takeshi
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依托单位:
Secretory cell differentiation and mucus secretion in cultures of human nasal epithelial cells.
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批准号:08671960
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$0.64万
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财政年份:1996
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负责人:SHIMIZU Takeshi
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依托单位:
Monoclonal antibodies as probes for studying human nasal secretions
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批准号:06671710
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
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财政年份:1994
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负责人:SHIMIZU Takeshi
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依托单位:
Study on the establishment of a therapeutic system for severe cardiac failure by means of artificial heart as a bridge to heart transplantation
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批准号:03454338
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.58万
-
财政年份:1991
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负责人:SHIMIZU Takeshi
-
依托单位:
The relationship between human ablities of left-handed and right-handed and functional assymmetry in hemisphers of the brain. - a study is to compare musical ability of left-handed and right-handed between the Japanese and foreigner (The American) -
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批准号:60450104
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项目类别:Grant-in-Aid for Scientific Research (B).
-
资助金额:$0.64万
-
财政年份:1985
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负责人:SHIMIZU Takeshi
-
依托单位:
海外基金