Histological and molecular biological study for standardization of pathological diagnosis of salivary gland tumors

为建立涎腺肿瘤的客观诊断标准，本研究采用组织学、免疫组化和分子病理学方法，分析了涎腺肿瘤中各种蛋白和基因的表达。结果表明，多种肌上皮标志物的表达和定位，多形性腺瘤中PLAG 1蛋白的过度表达，腺泡细胞癌中MUC蛋白的表达以及细胞增殖标志物Ki-67和geminin的评估有助于鉴别诊断和预测预后。阐明了细胞周期相关因子Aurora激酶的过度表达与肿瘤恶性程度的关系。

For establishment of objective diagnostic standards of salivary gland tumors, we analyzed the expression of various proteins and genes by histological, immunohistochemical and molecular pathological methods. The results indicated that the expression and localization of various myoepithelial markers, overexpression of PLAG1 protein in pleomorphic adenoma, MUC protein expression in acinic cell carcinoma and evaluation of cell proliferative markers including Ki-67 and geminin were useful for the differential diagnosis and the prediction of the prognosis. It was also clarified the relationship between overexpression of cell cycle related factors such as Aurora kinase and malignancy of the tumors.