Histological and molecular biological study for standardization of pathological diagnosis of salivary gland tumors

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For establishment of objective diagnostic standards of salivary gland tumors, we analyzed the expression of various proteins and genes by histological, immunohistochemical and molecular pathological methods. The results indicated that the expression and localization of various myoepithelial markers, overexpression of PLAG1 protein in pleomorphic adenoma, MUC protein expression in acinic cell carcinoma and evaluation of cell proliferative markers including Ki-67 and geminin were useful for the differential diagnosis and the prediction of the prognosis. It was also clarified the relationship between overexpression of cell cycle related factors such as Aurora kinase and malignancy of the tumors.