Effect of Renin-Angiotensin System in the bone metabolism

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The classical renin-angiotensin system (RAS) is a hormone system that maintains fluid balance and blood pressure. In addition to this classical RAS, many recent reports to suggested the existence of local RAS in several tissues. In our present study, we detected angiotensin II type 1 (AT1), AT2 receptor and angiotensin converting enzyme (ACE), which were the essential elements of local RAS, in osteoblasts. Angiotensin II (AII) stimulated some cellular signal molecules, such as ERK, AMPK and Syk, and promoted the expression of some chemokines in osteoblasts, whereas AII did not directly influence differentiation of osteoblast or chondrocyte. These results suggest that local RAS is functional in bone tissue.