Alterations of tooth development regulation associated with oncogenesis of odontogenic epithelium

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Regulators of tooth development were examined in oncogenesis and differetiation of odontogenic epithelium. Tooth germs and ameloblastomas expressed Notch receptors and their ligands chiefly in epithelial cells detached from the basement membrane. A stem cell-related molecule CD133 expression in malignanr ameloblastic tumors was significantly higher in tooth germs and ameloblastomas. ABCG2 did not react with toth germ epithelium, while some cases of ameloblastomas and malignant ameloblastic tumors showed positive reaction in neoplastoc cells. An autophagy-related molecule ATG5 expression in ameloblstomas and metastasizing ameloblastomas was slightly lower than in tooth germs. Granular neoplastic cells in ameloblastomas showed evident Beclin1 and ATG5 expression.