A study on a new management method for sedation with propofol using a target controlled infusion(TCI) pump for elderly patients

研究一采用新的异丙酚镇静管理方法，在较小的误差范围内预测术中最佳血药浓度，结果表明，最佳靶控血药浓度初始剂量为2.2μg/ml，即初始目标血药浓度为2.2μg/ml时，镇静水平计算的脑血药浓度与术中计算的血药浓度相差最小。两项研究结果之间的差异尚不清楚，但这可能是由于老年人的药效学和/或药代动力学效应的个体差异较大。

In study I for young and middle aged patients with a new management method for sedation with propofol predicting the optimal blood concentration during surgery within a small error range during induction, it was revealed that optimal initial dose of target blood concentration was 2.2μg/ml. That is, a maximum discrepancy between calculated brain concentration at the sedation level aimed for during induction and calculated blood concentration during surgery was the least when initial target blood concentration had been set at 2.2μg/ml. In study II for elderly patients with the same management method for sedation with propofol, it was not revealed which initial blood concentration is optimal. The differences of the results between the two studies were not clear, however, it may due to the large individual variance of the pharmacodynamic and/or pharmacokinetic effect in the elderly.