A study on a new management method for sedation with propofol using a target controlled infusion(TCI) pump for elderly patients

在研究I中，年轻和中年患者采用一种新的丙泊酚镇静管理方法，在诱导期间在较小的误差范围内预测手术期间的最佳血药浓度，结果显示，最佳靶血药浓度的初始剂量为2.2μg/ml。也就是说，当初始目标血液浓度设定为2.2μg/ml时，诱导期间目标镇静水平下计算的脑浓度与手术期间计算的血液浓度之间的最大差异最小。在研究II中，老年患者使用相同的丙泊酚镇静管理方法，未显示初始血药浓度是最佳的。两项研究结果的差异尚不清楚，但可能是由于老年人中药效学和/或药代动力学效应的个体差异较大。

In study I for young and middle aged patients with a new management method for sedation with propofol predicting the optimal blood concentration during surgery within a small error range during induction, it was revealed that optimal initial dose of target blood concentration was 2.2μg/ml. That is, a maximum discrepancy between calculated brain concentration at the sedation level aimed for during induction and calculated blood concentration during surgery was the least when initial target blood concentration had been set at 2.2μg/ml. In study II for elderly patients with the same management method for sedation with propofol, it was not revealed which initial blood concentration is optimal. The differences of the results between the two studies were not clear, however, it may due to the large individual variance of the pharmacodynamic and/or pharmacokinetic effect in the elderly.