Study on the channel-gating mechanism of the inositol-trisphosphate receptor

肌醇三磷酸受体通道门控机制的研究

• 批准号: 20700344
• 负责人: ENOMOTO Masahiro
• 金额: $ 1.66万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20700344/
• 关键词: 神経科学; 受容体; イオンチャネル; 細胞内カルシウム情報伝達; カルシウム放出; 神経化学; 細胞内カルシウムシグナル; IP_3受容体; カルシウムチャネル; チャネル開口機構; 分子内相互作

I have achieved the following outstanding outcomes from this research project. One is that "the interaction between regulatory domain and channel domain of IP_3R directly regulates the open-close transition.", and another is that " IP_3-binding domain of IP_3R is essential for the IP_3-induced Ca^<2+> release function, and the mutant lacking in this region shows the character of Ca^<2+>-induced Ca^<2+> release channel." These results are highly-impact outcomes that have firstly in the world elucidated the basic channel-gating mechanism of IP_3R.

我从这个研究项目中取得了以下突出成果。一是IP_3R的调控域与通道域之间的相互作用直接调控了IP_3R的开闭转换。另一种观点认为IP_3R的IP_3结合域是IP_3诱导Ca^<2+>释放功能所必需的，该区域缺失的突变体表现出Ca^<2+>诱导Ca^<2+>释放通道的特征。“这些结果是具有高度影响力的结果，在世界上首次阐明了IP_3R的基本通道门控机制。

项目成果

Neurotrophic Effect of Gonadotropin-Releasing Hormone on Neurite Extension and Neuronal Migration of Embryonic Gonadotropin-Releasing Hormone Neurons in Chick Olfactory Nerve Bundle Culture

• DOI: 10.1002/jnr.22051
• 发表时间: 2009-08-01
• 期刊: JOURNAL OF NEUROSCIENCE RESEARCH
• 影响因子: 4.2
• 作者: Kanaho, Yoh-Ichiro;Enomoto, Masahiro;Murakami, Shizuko
• 通讯作者: Murakami, Shizuko