Development of drug and gene delivery system for injured sites of cardiovascular tissues
Development of drug and gene delivery system for injured sites of cardiovascular tissues
批准号:
20700396
负责人:
ISE Hirohiko
金额:
$2.83万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
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英文摘要
Cardiomyocytes and vascular smooth muscle cells (VSMCs) were found to interact with N-acetylglucosamine (GlcNAc) using glycopolymers containing GlcNAc. It was assumed that these cells have GlcNAc-binding lectin on the cell surfaces. We tried to develop drug and delivery systems for injured site of cardiovascular tissue. The uptake of GlcNAc-conjugated liposomes to cardiomyocytes was observed. These results suggested the development of drug and gene delivery system for injured sites of cardiovascular tissues using GlcNAc-conjugated liposomes.
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Desmin and vimentin have N-acetylglucosamine-binding lectinic properties and are expressed on the cell surface
结蛋白和波形蛋白具有 N-乙酰氨基葡萄糖结合凝集素特性,并在细胞表面表达
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Ise H, Kobayashi S, Takahashi M, Aso S, Akaike T, Ikeda U]
通讯作者:
Ikeda U
Surface coating of bone marrow cells with N-acetylglucosamine for bone marrow implantation therapy
N-乙酰氨基葡萄糖表面涂层用于骨髓移植治疗
DOI:
--
发表时间:
2009
期刊:
Biomaterials 30
影响因子:
--
作者:
[Kobayashi S, Ise H*, Takahashi M, Goto M, Akaike T, Ikeda U]
通讯作者:
Ikeda U
DOI:
10.1093/glycob/cwq039
发表时间:
2010-07-01
期刊:
GLYCOBIOLOGY
影响因子:
4.3
作者:
[Ise, Hirohiko, Kobayashi, Satoshi, Akaike, Toshihiro]
通讯作者:
Akaike, Toshihiro
Surface coating of bone marrow cells with N-acetylglucosamine for bone marrow implantation therapy.
用 N-乙酰氨基葡萄糖表面涂覆骨髓细胞,用于骨髓植入治疗。
DOI:
--
发表时间:
2009
期刊:
Biomaterials 30
影响因子:
--
作者:
[Kobayashi s, Ise H, Takahashi M, Goto M, Akaike T, Ikeda U.]
通讯作者:
Ikeda U.
人工的な糖鎖修飾を行った骨髄細胞の心筋組織へのターゲティング法の開発
开发人工糖基化骨髓细胞靶向心肌组织的方法
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[小林聡, 伊勢裕彦他]
通讯作者:
伊勢裕彦他
共 20 条
Development of molecular targeting systm for various chonic diseases by GlcNAc-bearing polymer
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批准号:15K01313
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
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财政年份:2015
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负责人:ISE Hirohiko
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依托单位:
Elucidation of the physiological role of vimentin and desmin by artificial glycopolymers
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批准号:20200016
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项目类别:Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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资助金额:$18.39万
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财政年份:2008
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负责人:ISE Hirohiko
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依托单位:
Development of drug deliumy system for targeting to injured myocardium by a novel glycoside-binding protein
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批准号:18590764
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.43万
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财政年份:2006
-
负责人:ISE Hirohiko
-
依托单位:
海外基金