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Development of drug and gene delivery system for injured sites of cardiovascular tissues

Development of drug and gene delivery system for injured sites of cardiovascular tissues
心血管组织损伤部位药物和基因递送系统的开发
批准号:
20700396
负责人:
ISE Hirohiko
金额:
$2.83万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009

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中文摘要
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英文摘要
Cardiomyocytes and vascular smooth muscle cells (VSMCs) were found to interact with N-acetylglucosamine (GlcNAc) using glycopolymers containing GlcNAc. It was assumed that these cells have GlcNAc-binding lectin on the cell surfaces. We tried to develop drug and delivery systems for injured site of cardiovascular tissue. The uptake of GlcNAc-conjugated liposomes to cardiomyocytes was observed. These results suggested the development of drug and gene delivery system for injured sites of cardiovascular tissues using GlcNAc-conjugated liposomes.
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会议论文
Desmin and vimentin have N-acetylglucosamine-binding lectinic properties and are expressed on the cell surface
结蛋白和波形蛋白具有 N-乙酰氨基葡萄糖结合凝集素特性,并在细胞表面表达
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Ise H, Kobayashi S, Takahashi M, Aso S, Akaike T, Ikeda U]
通讯作者: Ikeda U
DOI: --
发表时间: 2009
期刊: Biomaterials 30
影响因子: --
作者: [Kobayashi S, Ise H*, Takahashi M, Goto M, Akaike T, Ikeda U]
通讯作者: Ikeda U
DOI: 10.1093/glycob/cwq039
发表时间: 2010-07-01
期刊: GLYCOBIOLOGY
影响因子: 4.3
作者: [Ise, Hirohiko, Kobayashi, Satoshi, Akaike, Toshihiro]
通讯作者: Akaike, Toshihiro
Surface coating of bone marrow cells with N-acetylglucosamine for bone marrow implantation therapy.
用 N-乙酰氨基葡萄糖表面涂覆骨髓细胞,用于骨髓植入治疗。
DOI: --
发表时间: 2009
期刊: Biomaterials 30
影响因子: --
作者: [Kobayashi s, Ise H, Takahashi M, Goto M, Akaike T, Ikeda U.]
通讯作者: Ikeda U.
20
    Development of molecular targeting systm for various chonic diseases by GlcNAc-bearing polymer
    • 批准号:
      15K01313
    • 项目类别:
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    • 资助金额:
      $3.16万
    • 财政年份:
      2015
    • 负责人:
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    • 依托单位:
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    • 批准号:
      20200016
    • 项目类别:
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    • 资助金额:
      $18.39万
    • 财政年份:
      2008
    • 负责人:
      ISE Hirohiko
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    • 批准号:
      18590764
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.43万
    • 财政年份:
      2006
    • 负责人:
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    • 依托单位:
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