Development of drug and gene delivery system for injured sites of cardiovascular tissues

心血管组织损伤部位药物和基因递送系统的开发

• 批准号: 20700396
• 负责人: ISE Hirohiko
• 金额: $ 2.83万
• 依托单位: Tokyo Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20700396/
• 关键词: 薬物輸送システム; N-アセチルグルコサミン; レクチン; 糖鎖高分子; ビメンチン; デスミン

Cardiomyocytes and vascular smooth muscle cells (VSMCs) were found to interact with N-acetylglucosamine (GlcNAc) using glycopolymers containing GlcNAc. It was assumed that these cells have GlcNAc-binding lectin on the cell surfaces. We tried to develop drug and delivery systems for injured site of cardiovascular tissue. The uptake of GlcNAc-conjugated liposomes to cardiomyocytes was observed. These results suggested the development of drug and gene delivery system for injured sites of cardiovascular tissues using GlcNAc-conjugated liposomes.

发现心肌细胞和血管平滑肌细胞（VSMCs）通过含有GlcNAc的糖共聚物与n -乙酰氨基葡萄糖（GlcNAc）相互作用。据推测，这些细胞表面有glcnac结合凝集素。我们试图开发针对心血管组织损伤部位的药物和输送系统。观察glcnac偶联脂质体对心肌细胞的摄取。这些结果提示利用glcnac偶联脂质体为心血管组织损伤部位提供药物和基因传递系统的发展。

项目成果

Desmin and vimentin have N-acetylglucosamine-binding lectinic properties and are expressed on the cell surface

结蛋白和波形蛋白具有 N-乙酰氨基葡萄糖结合凝集素特性，并在细胞表面表达

• 发表时间: 2008
• 作者: Ise H;Kobayashi S;Takahashi M;Aso S;Akaike T;Ikeda U
• 通讯作者: Ikeda U

Surface coating of bone marrow cells with N-acetylglucosamine for bone marrow implantation therapy

N-乙酰氨基葡萄糖表面涂层用于骨髓移植治疗

• 发表时间: 2009
• 期刊: Biomaterials 30
• 作者: Kobayashi S;Ise H*;Takahashi M;Goto M;Akaike T;Ikeda U
• 通讯作者: Ikeda U

Vimentin and desmin possess GlcNAc-binding lectin-like properties on cell surfaces

• DOI: 10.1093/glycob/cwq039
• 发表时间: 2010-07-01
• 期刊: GLYCOBIOLOGY
• 影响因子: 4.3
• 作者: Ise, Hirohiko;Kobayashi, Satoshi;Akaike, Toshihiro
• 通讯作者: Akaike, Toshihiro

Surface coating of bone marrow cells with N-acetylglucosamine for bone marrow implantation therapy.

用 N-乙酰氨基葡萄糖表面涂覆骨髓细胞，用于骨髓植入治疗。

• 发表时间: 2009
• 期刊: Biomaterials 30
• 作者: Kobayashi s;Ise H;Takahashi M;Goto M;Akaike T;Ikeda U.
• 通讯作者: Ikeda U.

人工的な糖鎖修飾を行った骨髄細胞の心筋組織へのターゲティング法の開発

开发人工糖基化骨髓细胞靶向心肌组织的方法

• 发表时间: 2008
• 作者: 小林聡;伊勢裕彦他
• 通讯作者: 伊勢裕彦他