Analysis of CD14 expression for the hyporesponsiveness against LPS in intestinal macrophage

点击翻译按钮获取中文摘要

The investigation was focused on the regulatory system of CD14 expression, which is a LPS receptor, for the analysis of LPS hyporesponsiveness of intestinal macrophages. These results suggested that CD14 in intestinal macrophages showed high molecular weight than control peritoneal macrophage and RAW264.7, and without sugar modification. Thus, it is suggested that there exists a new regulatory mechanism of posttranslational modification of CD14 for suppress excess response against foreign substances in tissue macrophages.