The effects of soy food and fish oil on lipid metabolism in livers and adipose tissues of rats

大豆食品和鱼油对大鼠肝脏和脂肪组织脂质代谢的影响

• 批准号: 20700615
• 负责人: TAKAHASHI Yoko
• 金额: $ 2.16万
• 依托单位: National Agricultural Research Organization
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20700615/
• 关键词: 健康と食生活; 凍り豆腐; 魚油; 肝臓; 遺伝子発現; 脂肪酸; コレステロール; 大豆タンパク質

We investigated how the simultaneous intake of soy protein and fish oil modulates lipid metabolism in rats. Compared with casein and palm oil, soy protein and fish oil significantly decreased serum lipid concentrations, respectively. Soy protein significantly reduced the activities and mRNA expressions of hepatic fatty acid synthetic enzymes compared with casein in palm oil diets, whereas fish oil strongly decreased the values regardless of protein sources. The supplementation of diets with fish oil significantly stimulated hepatic fatty acid oxidation at the level of enzymatic activity and mRNA expression, whereas soy protein significantly increased the activities of these enzymes, but not their mRNA expression. Freeze-dried tofu also showed hypolipidemic effect similar to soy protein. Therefore, simultaneous ingestion of soy protein (freeze-dried tofu) and fish oil generally had the greatest hypolipidemic effect among the dietary groups, although these actions were not synergistic.

我们研究了同时摄入大豆蛋白和鱼油如何调节大鼠的脂质代谢。与酪蛋白和棕榈油相比，大豆蛋白和鱼油分别显著降低血清脂质浓度。大豆蛋白显着降低了棕榈油饮食中的酪蛋白相比，肝脂肪酸合成酶的活性和mRNA的表达，而鱼油强烈降低的值，无论蛋白质来源。补充鱼油的饮食显着刺激肝脂肪酸氧化的酶活性和mRNA的表达水平，而大豆蛋白显着增加这些酶的活性，但不是他们的mRNA的表达。冻干豆腐也具有与大豆蛋白相似的降血脂作用。因此，同时摄入大豆蛋白（冻干豆腐）和鱼油通常具有最大的降血脂作用的饮食组，虽然这些行动是没有协同作用。

项目成果

食餌大豆タンパク質及び魚油がラット肝臓の脂質代謝に及ぼす影響

膳食大豆蛋白和鱼油对大鼠肝脏脂质代谢的影响

• 发表时间: 2009
• 作者: Takahashi Y;and Ide T.;高橋陽子;高橋陽子
• 通讯作者: 高橋陽子

Dietary soy components and lipid metabolism - analysis of gene expression

膳食大豆成分和脂质代谢 - 基因表达分析

• 发表时间: 2008
• 作者: Takahashi Y;and Ide T.;高橋陽子;高橋陽子;Yoko Takahashi
• 通讯作者: Yoko Takahashi

Effects of soy protein and isoflavone on hepatic fatty acid synthesis and oxidation and mRNA expression of uncoupling proteins and peroxisome proliferator-activated receptor gamma in adipose tissues of rats

大豆蛋白和异黄酮对大鼠肝脏脂肪酸合成和氧化以及脂肪组织中解偶联蛋白和过氧化物酶体增殖物激活受体γ mRNA表达的影响

• 发表时间: 2008
• 期刊: The Journal of Nutritional Biochemistry Vol.19、No.10
• 作者: Yoko Takahashi;Takashi Ide
• 通讯作者: Takashi Ide

凍り豆腐と魚油がラット肝臓の脂質代謝に及ぼす影響

冻豆腐和鱼油对大鼠肝脏脂质代谢的影响

• 发表时间: 2010
• 作者: Takahashi Y;and Ide T.;高橋陽子
• 通讯作者: 高橋陽子

A comparative analysis of genistein and daidzein in affecting lipid meta holism in rat liver

金雀异黄酮和大豆黄酮对大鼠肝脏脂质代谢影响的比较分析

• 发表时间: 2009
• 期刊: Journal of Clinical Biochemistry and Nutrition 44
• 作者: Takahashi Y;Odbayar TO;Ide T
• 通讯作者: Ide T