The elucidation of the mechanism for regulating lipid metabolism by whole soybean

全大豆调节脂质代谢机制的阐明

• 批准号: 22700777
• 负责人: TAKAHASHI Yoko
• 金额: $ 2.41万
• 依托单位: National Agriculture and Food Research Organization
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22700777/
• 关键词: 健康と食生活; 大豆; 食餌タンパク質; 食餌脂質; 脂質代謝; 肝臓; 遺伝子発現

To clarify the mechanism for regulating lipid metabolism by whole soybean, we compared the functionality of whole soybean with those of protein and lipid fractions by animal study using rats. The protein fraction and lipid fraction of soybean suppressed hepatic fatty acid synthesis. Thus, the suppression of hepatic fatty acid synthesis may contribute to the hypotriglyceridemic action of soybean. Soybean also reduced the level of triacylglyceride in liver, although soy protein isolated or purified soybean oil could not prevent the accumulation. As for cholesterol metabolism, the protein fraction lowered serum total cholesterol, while the soy lipid was likely to reduce non HDL-cholesterol fraction.

为了阐明全大豆调节脂质代谢的机制，我们通过大鼠动物研究比较了全大豆与蛋白质和脂质组分的功能。大豆的蛋白质组分和脂质组分抑制肝脂肪酸的合成。因此，肝脂肪酸合成的抑制可能有助于大豆的降血脂作用。大豆还降低了肝脏中甘油三酯的水平，尽管大豆分离蛋白或纯化大豆油不能阻止甘油三酯的积累。至于胆固醇代谢，蛋白质组分降低血清总胆固醇，而大豆脂质可能降低非HDL-胆固醇组分。

项目成果

Soy protein and fish oil independently decrease serum lipid concentrations but interactively reduce hepatic enzymatic activity and gene expression involved in fatty acid synthesis in rats.

大豆蛋白和鱼油独立地降低大鼠血清脂质浓度，但相互作用地降低肝酶活性和参与脂肪酸合成的基因表达。

• 发表时间: 2011
• 期刊: Journal of Nutritional Science and Vitaminology
• 影响因子: 1.6
• 作者: 中俣潤一;森本景之;興梠恵美;馬場良子;尾辻 豊;田村雅仁;土肥良秋;Yoko Takahashi
• 通讯作者: Yoko Takahashi

Tofu(soybean curd) lowers serum lipid levels and modulates hepatic gene expression involved in lipogenesis primarily through its protein not isoflavone component in rats

豆腐主要通过其蛋白质而非异黄酮成分降低大鼠血清脂质水平并调节参与脂肪生成的肝脏基因表达

• DOI: 10.1021/jf201403u
• 发表时间: 2011
• 期刊: Journal of Agricultural and Food Chemistry
• 影响因子: 6.1
• 作者: Yoko Takahashi;Tomokazu Konishi
• 通讯作者: Tomokazu Konishi

Soy protein and fish oil independently decrease serum lipid concentrations but interactively reduce hepatic enzymatic activity and gene expression involved in fatty acid synthesis in rats

大豆蛋白和鱼油独立降低大鼠血清脂质浓度，但交互降低参与脂肪酸合成的肝酶活性和基因表达

• 发表时间: 2011
• 期刊: Journal of Nutritional Science and Vitaminology
• 影响因子: 1.6
• 作者: 中俣潤一;森本景之;馬場良子;柴田達哉;鐘江 香;芹野良太;椛島成利;尾辻 豊;土肥良秋;田村雅仁;Yoko Takahashi
• 通讯作者: Yoko Takahashi

大豆の脂質代謝調節機能におけるタンパク質および脂質成分の役割

蛋白质和脂质成分在大豆脂质代谢调节功能中的作用

• 发表时间: 2012
• 作者: 高橋陽子;八巻幸二
• 通讯作者: 八巻幸二