The elucidation of the mechanism for regulating lipid metabolism by whole soybean

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To clarify the mechanism for regulating lipid metabolism by whole soybean, we compared the functionality of whole soybean with those of protein and lipid fractions by animal study using rats. The protein fraction and lipid fraction of soybean suppressed hepatic fatty acid synthesis. Thus, the suppression of hepatic fatty acid synthesis may contribute to the hypotriglyceridemic action of soybean. Soybean also reduced the level of triacylglyceride in liver, although soy protein isolated or purified soybean oil could not prevent the accumulation. As for cholesterol metabolism, the protein fraction lowered serum total cholesterol, while the soy lipid was likely to reduce non HDL-cholesterol fraction.