The association between TSP1 polymorphism and treatment efficacy of heart failure
The association between TSP1 polymorphism and treatment efficacy of heart failure
批准号:
20890115
负责人:
NONEN Shinpei
金额:
$2.11万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (Start-up)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
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英文摘要
I investigate the association between inter-individual variability of ss-blocker responsiveness in heart failure and TSP1 Thr523Ala polymorphism. I also perform in vitro functional analysis of TSP1 Thr523Ala. TSP1 Thr523Ala was associated with response to β-blockers in heart failure. Ala-523 TSP1 construct was lower in protein expression and translation efficacy than Thr-523 TSP1 construct.
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会议论文
心不全治療におけるβ遮断薬反応性の個人差とThrombospondin 1遺伝子多型との関連
心力衰竭治疗中β受体阻滞剂反应个体差异与血小板反应蛋白1基因多态性的关系
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[南畝晋平, 上野由香子, 岡本洋, 藤尾慈, 竹本恭彦, 葭山稔, 寺崎文生, 大塚薫, 岩尾洋, 東純一]
通讯作者:
東純一
心不全治療におけるβ遮断薬反応性の個人差とThrombospondin1遺伝子多型との関連
心力衰竭治疗中β受体阻滞剂反应个体差异与血小板反应蛋白1基因多态性的关系
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[南畝晋平, 上野由香子, 岡本洋, 藤尾慈, 竹本恭彦, 葭山稔, 寺崎文生, 大塚薫, 岩尾洋, 東純]
通讯作者:
東純
Prediction of the responsiveness to antidepressants by DNA methylation in patients with major depression
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批准号:24790541
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.58万
-
财政年份:2012
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负责人:NONEN Shinpei
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依托单位:
The association between genetic polymorphism and risk of progression to castration-resistant prostate cancer in Japanese men receiving androgen deprivation therapy.
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批准号:22790515
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.91万
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财政年份:2010
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负责人:NONEN Shinpei
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依托单位:
海外基金