The role of Interleukin-6 family cytokines in repair and tumorigenesis in the lung.

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Urethane-induced tumorigenesis was suppressed in the lungs of airway epithelium-specific knockout mice of Stat3 (Stat3^<Δ/Δ>) compared to control mice, suggesting that Stat3 in airway epithelium was required for the tumor growth in the lung. Immunohistochemistry did not show any significant differences in differentiation, proliferation or angiogenesis in the tumor. However, bronchoalveolar lavage (BAL) revealed that the local inflammation was significantly increased in the lung of Stat3^<Δ/Δ> compared to control mice, suggesting the possibility that tumor suppression was mediated by the increased inflammation in the lung of Stat3^<Δ/Δ>.