Ecology and pandemic planning of animal influenza virus

动物流感病毒的生态学和流行病规划

• 批准号: 15108004
• 负责人: KIDA Hiroshi
• 金额: $ 65.89万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (S)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15108004/
• 关键词: influenza viruses; global surveillance; vaccine; antiviral; diagnosis

H5N1 highly pathogenic avian influenza (HPAI) virus has spread in poultry from Southeast Asia to the north, Europe, and Africa. We have been conducting global surveillance of avian influenza and the assessment of pathogenicity of the H5 virus isolates in birds and mammals. In 2006, 55 avirulent avian influenza viruses were isolated from fecal sample of water birds. Thus, avian influenza viruses of 133 combinations of HA and NA subtypes have been stocked for use in vaccine and diagnosis.It was revealed that the H5N1 isolates in Mongolia in 2006 were closely related to each other and classified into the cluster of "Qinghai Lake" H5N1 viruses including those isolated in European, Mediterranean, African, and Asian countries. Swan/Mongolia/06 (H5N1) caused severe disease in ducks with 30% mortality. This virus replicated in upper respiratory tracts of pigs without any clinical signs.Rapid antigen detection kits for H5 and H7 influenza viruses were developed and their efficacy was investigated in the chickens experimentally infected with HPAI viruses. The results indicated that these antigen detection kits are useful tool for the diagnosis of influenza caused by H5 and H7 viruses.

H5 N1高致病性禽流感病毒已在从东南亚到北部、欧洲和非洲的家禽中传播。我们一直在全球监察禽流感，并评估H5病毒分离株对禽鸟和哺乳动物的致病性。2006年从水禽粪便中分离到55株禽流感病毒。结果表明，2006年蒙古国分离的H5 N1亚型禽流感病毒与欧洲、地中海、非洲和亚洲国家分离的H5 N1亚型禽流感病毒具有很强的亲缘关系，属于“青海湖”型禽流感病毒群。Swan/Mongolia/06（H5 N1）引起鸭的严重疾病，死亡率为30%。本研究建立了H5和H7流感病毒快速抗原检测试剂盒，并对HPAI病毒感染鸡进行了检测。结果表明，这些抗原检测试剂盒可用于H5和H7流感病毒的诊断。

项目成果

Improvement of a rapid diagnosis kit to detect either influenza a or B virus infections

• DOI: 10.1292/jvms.68.35
• 发表时间: 2006-01-01
• 期刊: JOURNAL OF VETERINARY MEDICAL SCIENCE
• 影响因子: 1.2
• 作者: Bai, GR;Sakoda, Y;Kida, H
• 通讯作者: Kida, H

Library of influenza virus strains for vaccine and diagnostic, use against highly pathogenic avian influenza and human pandemics.

用于疫苗和诊断的流感病毒株库，用于对抗高致病性禽流感和人类流行病。

• 发表时间: 2006
• 期刊: Dev Biol (Basel) 124
• 作者: Kida;H.;Sakoda;Y.
• 通讯作者: Y.

Hierarchy among viral RNA (vRNA) segments in their role in vRNA incorporation into influenza A virions

• DOI: 10.1128/jvi.80.5.2318-2325.2006
• 发表时间: 2006-03-01
• 期刊: JOURNAL OF VIROLOGY
• 影响因子: 5.4
• 作者: Muramoto, Y;Takada, A;Kawaoka, Y
• 通讯作者: Kawaoka, Y

Library of influenza virus strains for vaccine and diagnostic use against highly pathogenic avian influenza and human pandemics.

用于针对高致病性禽流感和人类流行病的疫苗和诊断用途的流感病毒株库。

• 发表时间: 2006
• 期刊: Dev Biol (Basel) 124
• 作者: Kida;H.;Sakoda;Y.
• 通讯作者: Y.

Pathogenicity of a highly pathogenic avian influenza virus, A/chicken/Yamaguchi/7/04 (H5N1) in different species of birds and mammals

• DOI: 10.1007/s00705-005-0723-6
• 发表时间: 2006-07-01
• 期刊: ARCHIVES OF VIROLOGY
• 影响因子: 2.7
• 作者: Isoda, N.;Sakoda, Y.;Kida, H.
• 通讯作者: Kida, H.