HMBA-induced erythroid differentiation decreases sphingosine kinase 1 gene expression of a mouse erythroleukemia cell line

HMBA 诱导的红细胞分化降低小鼠红白血病细胞系的鞘氨醇激酶 1 基因表达

• 批准号: 20890251
• 负责人: SOBUE Sayaka
• 金额: $ 2.11万
• 依托单位: Chubu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (Start-up)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20890251/
• 关键词: SPHK1; 赤白血病; 分子標的療法; sphingosine kinase 1; 白血病; 分化誘導療法

Friend cell is a mouse erythroleukemia cell line inducible to the erythroid lineage with HMBA. Increased expression of sphingosine kinase 1 (SPHK1), a sphingolipid metabolic enzyme, has been reported in Friend cells. In the current study, we analyzed the mechanism of its SPHK1 overexpression and the sequential changes during HMBA-induced differentiation.

Friend细胞是一种可用HMBA诱导红系的小鼠红白血病细胞系。鞘磷脂代谢酶SPHK1在Friend细胞中的表达增加。在本研究中，我们分析了其SPHK1过表达的机制以及在HMBA诱导分化过程中的时序变化。

项目成果

ATRA inhibits ceramide kinase transcription through an ATRA-related transcription factor, COUP-TF1, in a human neuroblastoma cell line, SH-SY5Y cells.

在人神经母细胞瘤细胞系 SH-SY5Y 细胞中，ATRA 通过 ATRA 相关转录因子 COUP-TF1 抑制神经酰胺激酶转录。

• 发表时间: 2008
• 作者: Sobue S;Murakami M;Banno Y;Ito H;Kimura A;Gao S;Furuhata A;Takagi A;Kojima T;Suzuki M;Nozawa Y;Murate T.;Sobue S;Iwasaki T;Sobue S;山井一晃;伊藤裕美;祖父江沙矢加;Hiromi Ito;Masashi Murakami
• 通讯作者: Masashi Murakami

ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells: the role of COUP-TFI

• DOI: 10.1111/j.1471-4159.2009.06486.x
• 发表时间: 2010-01-01
• 期刊: JOURNAL OF NEUROCHEMISTRY
• 影响因子: 4.7
• 作者: Murakami, Masashi;Ito, Hiromi;Murate, Takashi
• 通讯作者: Murate, Takashi

Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: relevance as a marker for daunorubicin sensitivity of leukemia cells

• DOI: 10.1007/s12185-008-0052-0
• 发表时间: 2008-04-01
• 期刊: INTERNATIONAL JOURNAL OF HEMATOLOGY
• 影响因子: 2.1
• 作者: Sobue, S.;Nemoto, S.;Murate, T.
• 通讯作者: Murate, T.

水素水投与後の血中水素濃度動態の検討

服用氢水后血氢浓度动态检查

• 发表时间: 2010
• 作者: 山井一晃;祖父江沙矢加;大桑哲男;市原正智
• 通讯作者: 市原正智

Characterization of myelodysplastic syndrome and aplastic anemia by immunostaining of p53 and hemoglobin F and karyotype analysis: Differential diagnosis between refractory anemia and aplastic anemia

通过 p53 和血红蛋白 F 免疫染色和核型分析表征骨髓增生异常综合征和再生障碍性贫血：难治性贫血和再生障碍性贫血的鉴别诊断

• DOI: 10.1111/j.1440-1827.2008.02236.x
• 发表时间: 2008
• 期刊: Pathology International
• 影响因子: 2.2
• 作者: T. Iwasaki;M. Murakami;C. Sugisaki;S. Sobue;H. Ohashi;H. Asano;Motoshi Suzuki;S. Nakamura;Masafumi Ito;T. Murate
• 通讯作者: T. Murate