The analysis for differentiation and function of human cytotoxic T lymphocytes under exposure to asbestos

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The effect of asbestos-exposure on CTL was investigated. Exposure to CB suppressed an increase in CD8^+ cell-number, cytotoxicity, increases in intracellular granzyme B and IFN-γ levels, and differentiation from naive cells to CTL. CB-exposure suppressed the productions of IL-10, IFN-γ, and TNF-α, but not IL-2. These results deny the possible contribution of IL-10, representative suppressive cytokine, to the suppressed induction of CTL, and indicate the potential of asbestos to inhibit the induction of CTL with decreases in IFN-γ and TNF-α, representative promoting cytokines. These suggest that inhaled asbestos might promote the generation of tumor disease by suppression of tumor-immunity.