Expression regulation and synthetic pathway of SIGIRR/TIR8, a negative regulator of Toll like receptor signaling

据报道，SIGIRR/TIR 8负调节Toll样受体（TLR）信号传导，其在炎症反应中起关键作用。然而，TLR信号传导过程中负责调节SIGIRR表达的精确机制仍然不清楚。在这项研究中，我们证实了作为TLR激活剂的脂多糖（LPS）对SIGIRR表达的调节。因此，LPS在转录水平下调SIGIRR的表达。此外，TLR信号下游的p38 MAP激酶和转录因子Sp1可能参与了LPS诱导的SIGIRR下调。

SIGIRR/TIR8 has been reported to negatively regulate Toll-like receptor (TLR) signaling, that plays critical role for inflammatory response. However, precise mechanism responsible for the regulation of SIGIRR expression during TLR signaling remains obscure. In this study, we confirmed the regulation of SIGIRR expression by Lipopolysaccharide (LPS), which is well known as a TLR activator. As a result, LPS down regulated SIGIRR expression at transcriptional level. Moreover, p38 MAP kinase downstream of TLR signaling, and transcriptional factor Sp1 were possibly involved in LPS induced SIGIRR down-regulation.