Applying the CCK framework to angiogenic-based therapeutics
Applying the CCK framework to angiogenic-based therapeutics
批准号:
LP0347380
负责人:
Prof David Craik
金额:
$20.94万
依托单位国家:
澳大利亚
项目类别:
Linkage Projects
财政年份:
2003
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2003-01-01 至 2006-05-14
中文摘要
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英文摘要
The aim of this project is to graft peptides involved in angiogenesis-related disorders onto a mini-protein framework. The cyclic cystine knot (CCK) framework is a plant based protein framework that has unique structural properties that make it exceptionally stable. The significance of this project is that the framework has the potential to overcome the limitations that are generally associated with peptide-based therapeutics, including poor stability and bioavailability. Vastly improved therapeutic leads may be produced from this approach.
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