Development of peptide-based scaffolds for intracellular cancer targets

开发基于肽的细胞内癌症靶标支架

• 批准号: nhmrc : 1084965
• 负责人: Prof David Craik
• 金额: $ 98.68万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-peptide-based-cancer-targets/519048
• 关键词: Development; peptide; based; scaffolds; intracellular

The overall aim of this project is to develop peptide-based drugs that are able to cross cell membranes and inhibit specific targets inside cells leading to more effective, safer and cost effective drugs for cancer. One potential outcome of the project will be new drug leads to treat melanoma and leukemia that are likely to be less toxic, more potent and less likely to develop resistance than current treatments.

该项目的总体目标是开发基于肽的药物，这些药物能够穿过细胞膜并抑制细胞内的特定靶点，从而产生更有效，更安全和更具成本效益的癌症药物。该项目的一个潜在成果将是治疗黑色素瘤和白血病的新药，这些药物可能比目前的治疗方法毒性更小，更有效，更不可能产生耐药性。