The chemistry and biology of circular proteins

环状蛋白质的化学和生物学

• 批准号: DP150100443
• 负责人: Prof David Craik
• 金额: $ 46.13万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150100443
• 关键词: chemistry; biology; circular; proteins

This project aims to develop plant-derived ultra-stable cyclic peptides for pharmaceutical and agricultural applications. The project will use innovative new methodologies for discovery, chemical synthesis and engineering of these molecules. It is expected that the project will contribute to high value biotechnology and agricultural industries in Australia. The proposed outcomes will include fundamental new knowledge on the biosynthesis of circular proteins in plants, new approaches for their discovery and technologies for applying them as drug leads and agricultural products.

该项目旨在开发用于制药和农业应用的植物源超稳定环肽。该项目将使用创新的新方法来发现，化学合成和这些分子的工程。预计该项目将有助于澳大利亚的高价值生物技术和农业产业。拟议的成果将包括关于植物中环状蛋白生物合成的基本新知识，发现它们的新方法以及将它们用作药物先导和农产品的技术。