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Discovery of novel circular proteins in bacteria, plants and animals: applications in drug design and crop protection

Discovery of novel circular proteins in bacteria, plants and animals: applications in drug design and crop protection
在细菌、植物和动物中发现新型环状蛋白:在药物设计和作物保护中的应用
批准号:
DP0449500
负责人:
Prof David Craik
金额:
$121.64万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2004
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2004-07-31 至 2009-07-30

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中文摘要
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英文摘要
The overall goal is to use innovative methods in chemistry, biochemistry and molecular biology to determine the structures and functions of several families of circular proteins that have exciting pharmaceutical and agricultural applications. These molecules differ from conventional proteins in that they have no ends: their termini are seamlessly joined, thereby making them exceptionally stable and resistant to enzyme digestion. The big question is ?How and why does Nature produce circular proteins?" Increasing our knowledge of why circular proteins have evolved will facilitate their applications in drug design and in the development of novel insecticides.
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