Biological mechanisms underlying extinction and reconsolidation processes of emotional memory
Biological mechanisms underlying extinction and reconsolidation processes of emotional memory
批准号:
21530758
负责人:
YAMADA Kazuo
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
利用经典恐惧条件反射和条件位置偏好研究了大鼠愉快或厌恶情绪记忆消退和/或重新巩固的神经机制。结果表明:(1)再巩固窗口期的消退有助于CS间消退的泛化;(2)NMDA受体激动剂可以促进恐惧反应的消退;(3)多巴胺D1和D2受体分别参与甲基苯丙胺诱导CPP的获得和恢复。
英文摘要
Neural mechanisms underlying extinction and/or reconsolidation of euphoric or aversive emotional memory were investigated using classical fear conditioning and conditioned place preference in rats. Results showed that (1) the extinction during the reconsolidation window could facilitate a generalization of the extinction between CS's, (2) NMDA receptor agonist could facilitate extinction of fear responses, (3) dopamine D1 and D2 receptors were involved in an acquisition and reinstatement of metamphetamine-induced CPP, respectively.
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Effects of adrenalectomy on stress-induced enhancement of conditioned fear response in rats. Society for Neuroscience
肾上腺切除术对应激诱导的大鼠条件性恐惧反应增强的影响。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Ryoke, R., Yamada, K. & Ichitani, Y.]
通讯作者:
Y.
高次神経機能とホルモン、『脳とホルモンの行動学:行動神経内分泌学への招待』第17章
高级神经功能和激素,“大脑行为和激素:行为神经内分泌学的邀请”第 17 章
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[山田一夫, 近藤保彦, 他]
通讯作者:
他
Nicotine improves AF64A-induced spatial memory deficits in Morris water maze in rats.
尼古丁可改善莫里斯水迷宫中 AF64A 诱导的大鼠空间记忆缺陷。
DOI:
--
发表时间:
2010
期刊:
Neuroscience Letters 469
影响因子:
--
作者:
[山田一夫, Furukawa, S., Iwasaki, T., 一谷幸男]
通讯作者:
一谷幸男
Evidence of directed forgetting in rats : Delayed nonmatching-to-position and delay-interposed radial maze tasks
大鼠定向遗忘的证据:延迟不匹配位置和延迟插入径向迷宫任务
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kaku, M., Yamada, K. & Ichitani, Y.]
通讯作者:
Y.
Long-lasting effects of traumatic stress on subsequent fear conditioning in rats
创伤应激对大鼠随后的恐惧调节的长期影响
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Ryoke, R., Yamada, K. & Ichitani, Y.]
通讯作者:
Y.
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Identification of susceptibility genes for psychiatric diseases on chromosome 18
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Prevention of apoptosis by p21 gene tranfer in central nervous system
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Application of FGF to the restoration of ischemic brain damage
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GENE REGULATION UNDER THE HIGH INTRACRANIAL PRESSURE
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Trial of neuronal regeneration after spinal cord injury by implantation of cultured astrocytes and by neurotrophic factor
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