Psychological and physiological studies on circadian rhythm in the memory system

据报道，被认为是记忆的生理基础的候选者的海马长时程增强（LTP）在褪黑激素的存在下减少，褪黑激素的分泌模式显示昼夜节律。在这项研究中，我的电生理机制的抑制海马LTP的褪黑激素。NO合成酶抑制剂和褪黑素的抑制作用被彼此阻断，并且NO供体破坏了LTP的抑制，这导致了褪黑素抑制LTP的靶点是NO通路的想法。

Hippocampal long-term potentiation(LTP), which is thought of as a candidate for the physiological basis of memory, is reportedly reduced in the presence of melatonin, whose pattern of secretion shows a circadian rhythm. In this study, I electrophysiologically examined the mechanisms of inhibition of hippocampal LTP by melatonin. The inhibitory effects of an inhibitor of NO synthase and melatonin were occluded by each other, and an NO donor disrupted the inhibition of LTP, which leads to the idea that the target of melatonin for LTP inhibition is the NO pathway.