Application of the brain functional analysis of autism spectrum disorders in order to establish an efficient medical and educational support system

我们首先利用近红外光谱对高功能ASD受试者与对照组进行比较，根据几何图形的工作记忆（WM）和非WM任务的相互配置，检测前额叶血流动力学变化。在任务切换的反应中，对照组立即观察到诱发脑血氧（CBO）的变化，而在ASD受试者中则没有，尽管任务表现率几乎相同。其次，在同样的转换任务中，我们测量了面部表情作为刺激时CBO的变化。在ASD患者中，任务执行率与CBO变化之间没有相关性，这在对照组中得到了证实。

We first examined prefrontal hemodynamic change according to reciprocal disposition of working memory(WM) and non-WM tasks of geometrical figures using near-infrared spectroscopy to compare high-functioning ASD subjects with controls. An evoked cerebral blood oxygenation(CBO) change was instantly observed in response to the task switch in the controls but not in ASD subjects, although the task performance rates were almost equivalent. Secondary, we measured CBO changes during facial expressions as stimuli in the same switching task. In ASD patients, no relevance between the task performance rate and the CBO change, which was shown in the controls.