Analysis of RagA, B/C, D in mTOR signal transduction system

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The objective of this research was to find when, where, and how the G proteins(RagA, B/C, D) regulate mTOR signal transduction pathway. Moreover, we tried to identify roles of interacting proteins of the G proteins in mTOR pathway.We elucidated significance of Gtrlp and Gtr2p complex formation and interaction to other proteins(Ego3 and Egol) by using G protein mutant proteins.We found that Gtrlp interacted to Torl complex proteins Kogl and Tco89 in a specific manner. Interaction between Gtrlp and Tco89p was important.We showed that human RagA, C regulate mTOR and AMPK. It was shown that AMPK regulates mTOR. Here we found that RagA, C could be bridge proteins for mTOR and AMPK.