Cell fate decision mechanism by the transcription factor E2F in cell growth and tumor suppression

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We analyzed the molecular mechanism of control of cell growth and tumor suppression mediated by the transcription factor E2F, the main target of the tumor suppressor pRB. We identified 5 novel genes, which are specifically activated by E2F induced by loss of pRB function, a representative oncogenic change. Many of these gene products are involved in the p53 pathway, which induces cell death. PI3 kinase pathway did not suppress activation of tumor suppressor genes by E2F induced by loss of pRB function.