The role of P2X receptor in overactive bladder and application of drugs targeting the receptor

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We examined the involvement of ATP receptor P2X_3 and vanilloid receptor TRPV1 in frequent voiding and pain accompanied with voiding in 4 models of frequent micturition of rats. Major findings are that pain during micturition increases the frequency of voiding and that the involvement of P2X_3 or TRPV1 varies depending of the type of micturition. Therefore, a drug targeting frequent voiding has to be determined depending on the pathogenesis of overactive bladder.