Studies on endothelin for clinical use

内皮素的临床应用研究

• 批准号: 21580369
• 负责人: UCHIDE Tsuyoshi
• 金额: $ 3.08万
• 依托单位: Rakuno Gakuen University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21580369/
• 关键词: 獣医学; 伴侶動物; 内科学; 呼吸循環器; 腫瘍; エンドセリン; 循環器

Endothelin-1(ET-1) is a bioactive peptide derived from vascular endothelial cells. Although ET-1 has recently received a lot of attention in human medicine because of its involvement in the pathophysiology of many diseases including heart failure, pulmonary hypertension, renal failure and tumors, no detailed studies on the clinical importance of ET-1 have been performed in veterinary medicine. In this study we investigated the feasibility of using ET-1 as a novel clinical marker to diagnose or assess the prognosis in canine cardiopulmonary and neoplastic disease. Dogs affected with cardiopulmonary disease, mitral valve regurgitation, tricuspid valve regurgitation and pulmonary hypertension, showed a significant increase in serum ET-1 levels compared to healthy dogs. In dogs presenting with hemangiosarcoma, a tumor that originates from vascular endothelial cells, significantly higher serum levels of ET-1 were observed than in dogs with non-neoplastic diseases or with neoplastic diseases other than hemangiosarcoma. Our observations suggest that serum ET-1 levels could be a novel clinical marker for these diseases.

内皮素-1（ET-1）是一种来源于血管内皮细胞的生物活性肽。虽然ET-1最近在人类医学中受到了很多关注，因为它参与了许多疾病的病理生理学，包括心力衰竭、肺动脉高压、肾衰竭和肿瘤，但在兽医学中还没有对ET-1的临床重要性进行详细的研究。在这项研究中，我们探讨了使用ET-1作为一种新的临床标志物，诊断或评估犬心肺和肿瘤疾病的预后的可行性。患有心肺疾病、二尖瓣反流、三尖瓣反流和肺动脉高压的犬与健康犬相比，血清ET-1水平显著升高。在患有血管肉瘤（一种起源于血管内皮细胞的肿瘤）的犬中，观察到ET-1的血清水平显著高于患有非肿瘤性疾病或患有血管肉瘤以外的肿瘤性疾病的犬。我们的观察表明，血清ET-1水平可能是一个新的临床指标，这些疾病。

项目成果

Anaplastic atypical myeloma with extensive cutaneous involvement in a dog

狗伴有广泛皮肤受累的间变性非典型骨髓瘤

• 发表时间: 2012
• 期刊: J Vet Med Sci
• 影响因子: 1.2
• 作者: Fukumoto S;Hanazono K;Kawasaki N;Hori Y;Higuchi S;Sasaki T;Temma K;Uchide T.
• 通讯作者: Uchide T.

Elevated endothelin-1 expression in dogs with naturally occurring cardiovascular disorders

患有自然发生的心血管疾病的狗中内皮素-1 表达升高

• 发表时间: 2009
• 作者: Uchide;T;Saida;K;Sasaki;T;Temma;K.
• 通讯作者: K.

人用シスタチンC検査試薬の犬への応用と実用性の検討

人胱抑素C检测试剂在犬中的应用及实用性

• 发表时间: 2009
• 作者: 内田英二;山倉麻由美;華園究;町田竜彦;松田憲児;打出毅
• 通讯作者: 打出毅

尿検査

尿液分析

• 发表时间: 2012
• 期刊: SA Medicine
• 作者: 華園究;打出毅
• 通讯作者: 打出毅

胸腔の腫瘍

胸腔肿瘤

• 发表时间: 2012
• 期刊: SA Medicine
• 作者: 華園究;打出毅
• 通讯作者: 打出毅