Pharmacokinetic analysis of the pharmacodynamic difference of opioids in dogs and cats

阿片类药物诱导犬的剂量依赖性抗伤害感受效应和意识水平、活动、心率和呼吸频率的抑制。相比之下，高剂量阿片类药物对猫的抗伤害感受作用较弱，对意识水平、活动、心率和呼吸频率的抑制作用较小。药代动力学分析结果表明，这种药效学差异主要不是由药代动力学差异引起的，而是由阿片受体分布或功能的差异引起的。

Opioids induced dose-dependent antinociceptive effect and depression of conscious level, activity and heart rate and respiratory rate in dogs. In contrast, opioids induced weak antinociceptive effect and less depression of conscious level, activity, heart rate and respiratory rate even at higher dose of opioids in cats. Results of pharmacokinetic analysis have indicated that this pharmacodynamics difference is not caused by pharmacokinetic difference mainly, but rather by difference of the opioid receptor distribution or function.