Analysis of molecules involved in neuronal polarity formation : a study using neuronal specific knockout mice

建立神经元的极性需要多种蛋白质。在这项研究中，我们分析了缺乏VAMP7的小鼠，VAMP7是一种被认为参与轴突运输的蛋白质。与预期相反，VAMP7基因敲除小鼠在神经系统中显示出类似的轴突蛋白定位。然而，培养的突变型海马神经元的突起生长受到轻微的影响，提示VAMP7在轴突蛋白的极化运输中具有一定的作用。这项研究发表在国际细胞内运输杂志《交通》上。

Various proteins are required in the establishment of neuronal polarity. In this study, we analyzed mice deficient in VAMP7, a protein proposed to be involved in axonal transport. Contrary to expectations, VAMP7 knockout mice displayed similar localization of axonal proteins in the nervous system. However, neurite outgrowth of cultured mutant hippocampal neurons was slightly affected, suggesting that VAMP7 have some role in polarized transport of axonal proteins. This work was published in Traffic, an international journal of intracellular transport.