Identification of adaptor molecules involved in intracellular transport of cadherins

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E-cadherin is a member of the cadherin family cell-cell adhesion molecules. After synthesis in rough endoplasmic reticulum, E-cadherin is transported to the baso-lateral membrane of epithelial cells, and forms cell adhesion complex called adherens junction. Cadherins forms complexes with α-catenin through the interaction with β-catenin. Uncoupling of β-catenin-binding results in failure of cadherin transport to the cell surface. Chimeric molecules of E-cadherin with α-catenin, however, are transported to the surface. Thus complex formation of cadherins with α-catenin is critical for the transport.