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Characteristics of gastrointestinal T or NK/T cell lymphoma and an influence of Helicobacter pylori infection

胃肠道T或NK/T细胞淋巴瘤的特点及幽门螺杆菌感染的影响

基本信息

批准号：
21590390
负责人：
TAKESHITA Morishige
金额：
$ 1.75万
依托单位：
Fukuoka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2011
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590390/
关键词：
intestine malignant lymphoma c-Met MAP kinase c-Myc H. pylori FISH CGH gastric lymphoma intestinal lymphoma H pylori East Asian CagA gene East Asian VacA gene

项目摘要

Coeliac disease and associating enteropathy-associated T-cell lymphoma(EATL) are frequently found in European Caucasians. Approximately 80% of enteropathy-associated T-cell lymphoma(EATL) cases present with CD56-negative, CD8-negative and CD30-positive large-cell lymphoma(type I). The remaining cases are classified as type II EATL and they present with CD56-and CD8-positive and CD30-negative monomorphic medium-sized lymphomas. In examined 32 cases of Japanese EATL, type II(CD56-and CD8-positive, CD30-negative medium-sized) lymphoma was common(85%) in Japan. HLA DQB102 homo-, heterozygosities and chromosomal amplification of 9q33-34, which are encountered in the Caucasian cases, were absent in the examined cases of Japanese EATL. Asian EATL cases are associated with peculiar pathological and genetic findings as well as histological features. Bacterial cytotoxic associated gene(Cag) A of East Asian H. pylori contributes to neoplastic transformation of gastric epithelium through the proto-oncogene c-Met, tyrosine kinase(p-SHP) 2 and mitogen-activated protein kinase(MAPK) pathway. Enteropathy-like lesions and CagA of East Asian H. pylori were detected in about half cases of tumor tissue in EATL, and expressions of c-Met, p-SHP2 and MAPK as well as chromosomal amplifications of c-Met(7q31) and c-Myc(8q24) were frequently found in cases of EATL. Intestinal bacterial florae including H. pylori may influence tumorgenesis in EATL.

乳糜泻和相关肠病相关T细胞淋巴瘤（EATL）常见于欧洲高加索人。大约80%的肠病相关T细胞淋巴瘤（EATL）病例表现为CD 56阴性、CD 8阴性和CD 30阳性大细胞淋巴瘤（I型）。其余病例归类为II型EATL，表现为CD 56和CD 8阳性和CD 30阴性单形中型淋巴瘤。在检查的32例日本EATL中，II型（CD 56和CD 8阳性，CD 30阴性中型）淋巴瘤在日本很常见（85%）。在日本EATL患者中，没有发现白种人病例中常见的HLA-DQB 102纯合性、杂合性和9 q33 -34染色体扩增。亚洲EATL病例与特殊的病理学和遗传学发现以及组织学特征相关。东亚血吸虫的细菌细胞毒性相关基因（Cag）A。幽门螺杆菌通过原癌基因c-Met、酪氨酸激酶（p-SHP）2和丝裂原活化蛋白激酶（MAPK）途径参与胃上皮的肿瘤转化。东亚H. pylori阳性率约为50%; c-Met、p-SHP 2和MAPK的表达以及c-Met（7 q31）和c-Myc（8 q24）的染色体扩增在EATL中较常见。肠道菌群包括H. pylori可能影响EATL的肿瘤发生。