Reaction mechanisms and structural analysis of abnormal immunoglobulins that reacts with measuring reagent.

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Routinely examination, there are many that show abnormal values not reflect the disease for measuring reagent to react with an abnormal protein(especially immunoglobulins). We analyzed the two cases of abnormal immunoglobulins, one case was found to be due to ionic bond with the sulfate group of an agar gel component and the patientγchain of IgG molecules. Another case, it is due to hydrophobic bonding with a linear alkyl group of SDS that is included in the reagent for measuring bilirubin and the patientμchain of IgM molecules was revealed.