Study on discharged antimicrobials into aquatic environment and presence of antimicrobial-resistant organisms

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This study revealed the following four points. Firstly, the environment where we live has been polluted with antimicrobials and the concentrations were less than detection limit by LC-MS/ MS. Secondly, there was possibility that antimicrobials could not appropriately removed at water-treatment plants. Thirdly, the isolated gram-negative bacilli showed resistance to antimicrobials whose concentrations were undetectable by LC-MS/ MS. Fourthly, quite a few bacilli were not sensitive to Quinolones and Carbapenems, and these MDROs might threaten human health.