Comprehensive analysis of pathogenesis and etiology of Takotsubo Cardiomyopathy by use of experimental model animal

本研究通过应激诱导大鼠模型，探讨Takotsubo心肌病的发病机制和病因。血管α1肾上腺素能受体的激活或心脏β1肾上腺素能受体的激活是情绪应激引起心脏和血管基因谱改变的主要原因。杏仁核各亚核接受来自边缘系统其他脑区的心理信息，而外侧亚核和中央亚核接受外周和感觉信息。下丘脑和周围交感神经系统的输出主要来自内侧杏仁核。

We investigated the pathogenesis and etiology of Takotsubo Cardiomyopathy by use of stress-induced rat model. Activation of α1-adrenoceptor in the blood vessels or activation ofβ1-adrenoceptors in the heart was mainly responsible for emotional stress-induced alteration of cardiac and vascular genes profiles. All amygdalid subncleui receive psychological information from other limbic brain, while the lateral and central subnuclei receive peripheral and sensory information. Output to the hypothalamus and peripheral sympathetic system mainly originates from the medial amygdala.