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Investigation for anti-renal fibrotic effects of lipid-binding proteins and lipid-activated nuclear receptors and search for new therapeutic reagents

Investigation for anti-renal fibrotic effects of lipid-binding proteins and lipid-activated nuclear receptors and search for new therapeutic reagents
研究脂质结合蛋白和脂质激活核受体的抗肾纤维化作用并寻找新的治疗试剂
批准号：
21591024
负责人：
KIMURA Hideki
金额：
$2.83万
依托单位：
University of Fukui
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2009
资助国家：
日本
项目状态：
已结题
起止时间：
2009 至 2011
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591024/
关键词：
腎臓学ペルオキシゾーム増殖剤応答性受容体脂肪酸結合蛋白尿細管上皮細胞メサンギウム細胞炎症アンジテンシンII受容体拮抗薬肝X受容体(LXR)ペルオキシゾーム増殖薬活性化受容体(PPAR)PAI-1MCP-1低酸素TNF-αTGF-βファルネソイドX受容体(FXR)プラスミノーゲンアクチベーターインヒビタ-1(PAI-1)プラスミノーゲンアクチベーターインヒビター1(PAI-1)

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中文摘要
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英文摘要
Presence and activities of peroxisome proliferator-activated receptor(PPAR)-δandγwere confirmed in human proximal renal tubular epithelial cells and mesangial cells which inflammatory insults targeted mainly during progression of renal injury. An angiotensin II receptor blocker, telmisartan was shown to have PPAR-δandγ-induced transcriptional activities and increase expression of their target genes such as fatty acid-binding protein(FABP) and liver X receptor. Telmisartan also decreased gene expression of monocyte chemoattractant protein-1(MCP-1). In the mouse immortalized proximal renal tubular cell line with over-expression of human liver-type FABP, a putative transporter of PPAR ligands, mouse PPAR-δwas up-regulated and MCP-1 down-regulated. These results suggest that some bioactive molecules with a potential to affect function and dynamism of PPAR and FABP are candidates of new therapeutic reagents for chronic kidney disease.
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Discrete Regulation of VEGF-A and-C in Human Proximal Renal Tubular Cells under Hypoxic and/or Inflammatory Conditions.-Inhibitory Effects of Glucocorticoids on Basal and Inducible VEGF Expression-
缺氧和/或炎症条件下人近端肾小管细胞中 VEGF-A 和-C 的离散调节。-糖皮质激素对基础和诱导 VEGF 表达的抑制作用-
DOI： --
发表时间： 2010
期刊：
影响因子： --
作者： [SaitoA, Kaseda R, Hosoiima M, Sato H, Tanaka M, Tanizaki J, 川本進也, Hideki Kimura]
通讯作者： Hideki Kimura
Tubulointerstitial nephritis with IgM-positive plasmacytoid large lymphocyte infiltration in a patient with primary biliary cirrhosis and Sjogren's syndrome
原发性胆汁性肝硬化伴干燥综合征患者肾小管间质性肾炎伴 IgM 阳性浆细胞样大淋巴细胞浸润
DOI： --
发表时间： 2010
期刊： Clin Nephrol
影响因子： 1.1
作者： [Takahashi N, Kimura H]
通讯作者： Kimura H
Overexpression of Human Liver-Fatty Acid-Binding Protein endogenously Enhances Peroxisome Proliferator Activated Receptor-αActivity possibly via inducing Hepatocyte Nuclear Factor-4αin Immortalized Mouse Proximal Renal Tubular Cells
人肝脏脂肪酸结合蛋白的过度表达可能通过诱导永生化小鼠近端肾小管细胞中的肝细胞核因子-4α内源性增强过氧化物酶体增殖物激活受体-α活性
DOI： --
发表时间： 2011
期刊：
影响因子： --
作者： [Kazuhito Totsune, 他7名, Kimura H]
通讯作者： Kimura H
Smaller LDL size as a possible risk factor for the prevalence of coronary artery diseases in hemodialysis patients-Associations of CETP and the hepatic lipase gene polymorphism with LDL size
较小的LDL大小可能是血液透析患者冠状动脉疾病患病的危险因素-CETP和肝脂肪酶基因多态性与LDL大小的关联
DOI： 10.1111/j.1440-1797.2011.01454.x
发表时间： 2011
期刊： Nephrology(Carlton)
影响因子： --
作者： [Kimura H, Miyazaki R, Imura T, Masunaga S, Shimada A, Mikami D, Kasuno K, Takahashi N, Hirano T, Yoshida H]
通讯作者： Yoshida H
共 18 条
    Analysis of anti-fibrotic effects of lipid-responsible transcription factors and a search for new therapeutic agents -with special attention to hypoxic insults-
    • 批准号：
      24591193
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $3.33万
    • 财政年份：
      2012
    • 负责人：
      KIMURA Hideki
    • 依托单位：
      University of Fukui
    Diachronic Changes and Panchronic Universal Properties of Constructions and Grammatical Categories in Chinese-a Reconstruction of Historical Chinese Grammar
    • 批准号：
      19320057
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $11.9万
    • 财政年份：
      2007
    • 负责人：
      KIMURA Hideki
    • 依托单位：
      The University of Tokyo
    Analysis for anti-inflammatory and anti-fibrotic actions of lipid transfer proteins and lipid-activated transcription factors in the progressive renal injury
    • 批准号：
      19590944
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $2.83万
    • 财政年份：
      2007
    • 负责人：
      KIMURA Hideki
    • 依托单位：
      University of Fukui
    Investigation on anti-inflammatory effects of lipid-binding proteins and lipophilic transcriptional factors in progression of renal injury.
    • 批准号：
      17590823
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $2.18万
    • 财政年份：
      2005
    • 负责人：
      KIMURA Hideki
    • 依托单位：
      University of Fukui