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Elucidation of the interaction between abnormalities of apolipo-protein E and Fc receptors on the development of lipoprotein glomerulopathy.

Elucidation of the interaction between abnormalities of apolipo-protein E and Fc receptors on the development of lipoprotein glomerulopathy.
阐明载脂蛋白 E 和 Fc 受体异常与脂蛋白肾小球病发生之间的相互作用。
批准号:
21591049
负责人:
SAITO Takao
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
In FcRγ/apoE-KO mice, human apoE3-injection showed the most drastic changes mimicking lipoprotein glomerulopathy as well as prominent hypertriglyceridemia. These results suggest that the impairment of macrophage function resulting from FcRγdeficiency plays a principal role in the development of LPG in the presence of apoE abnormalities. This may be another aspect of macrophage-induced dyscondition in dyslipidemia.
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Polymorphism of apolipoprotein E(apoE) variants in lipoprotein glomerulo-pathy(LPG)
脂蛋白肾小球病 (LPG) 中载脂蛋白 E (apoE) 变异体的多态性
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [野田裕美, 江渡加代子, 堀川三郎, 佐々木成, Takao Saito]
通讯作者: Takao Saito
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [森永潤, 實吉拓, 冨田公夫(他9名), Kenji Ito]
通讯作者: Kenji Ito
DOI: 10.1007/s10157-009-0195-1
发表时间: 2009-10-01
期刊: CLINICAL AND EXPERIMENTAL NEPHROLOGY
影响因子: 2.3
作者: [Ishimura, Atsunori, Watanabe, Maho, Saito, Takao]
通讯作者: Saito, Takao
Macroage impairment produced by Fc receptor gamma deficiency plays a principal role in the development of lipoprotein glomerulopathy in concert with apoE abnormalities
Fc 受体 γ 缺乏引起的巨龄细胞损伤在脂蛋白肾小球病的发生中起主要作用,并与 apoE 异常相关
DOI: --
发表时间: 2012
期刊: Nephrol Dial Transplant
影响因子: --
作者: [Ito K, Nakashima H, Watanabe M., Ishimura A., Miyahara Y., Abe Y., Yasuno T., Ifuku M, Saito T.]
通讯作者: Saito T.
15
    Legal Systems to Balance Grassland Landscape Preservation with Ger Camp Development in Mongolia and Inner Mongolia
    • 批准号:
      22402011
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $5.57万
    • 财政年份:
      2010
    • 负责人:
      SAITO Takao
    • 依托单位:
    Development of a novel method for analyzing murine lipoprotein profile and application for an experimental model of lipoprotein glomerulopathy
    • 批准号:
      18590917
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.44万
    • 财政年份:
      2006
    • 负责人:
      SAITO Takao
    • 依托单位:
    TCR-ζ EXPRESSION AND APOPTOSIS IN PERIPHRAL BLOOD MONONUCLEAR CELLS OF PATIENTS WITH HEAD AND NECK CANCER
    • 批准号:
      14571639
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.18万
    • 财政年份:
      2002
    • 负责人:
      SAITO Takao
    • 依托单位:
    A STUDY ON SYNTHESIS OF HETEROCYCLES VIA CROSS-CONJUGATED HETEROTRIENES AND FUNCTIONALIZED CARBODIIMIDES AS KEY INTERMEDIATES
    • 批准号:
      14540504
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.11万
    • 财政年份:
      2002
    • 负责人:
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    • 依托单位:
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