Elucidation of the interaction between abnormalities of apolipo-protein E and Fc receptors on the development of lipoprotein glomerulopathy.
Elucidation of the interaction between abnormalities of apolipo-protein E and Fc receptors on the development of lipoprotein glomerulopathy.
批准号:
21591049
负责人:
SAITO Takao
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
In FcRγ/apoE-KO mice, human apoE3-injection showed the most drastic changes mimicking lipoprotein glomerulopathy as well as prominent hypertriglyceridemia. These results suggest that the impairment of macrophage function resulting from FcRγdeficiency plays a principal role in the development of LPG in the presence of apoE abnormalities. This may be another aspect of macrophage-induced dyscondition in dyslipidemia.
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Polymorphism of apolipoprotein E(apoE) variants in lipoprotein glomerulo-pathy(LPG)
脂蛋白肾小球病 (LPG) 中载脂蛋白 E (apoE) 变异体的多态性
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[野田裕美, 江渡加代子, 堀川三郎, 佐々木成, Takao Saito]
通讯作者:
Takao Saito
Fc receptor gamma chain deficiency is related tohe development of lipoprotein glomerulopathy
Fc受体γ链缺陷与脂蛋白肾小球病的发生有关
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[森永潤, 實吉拓, 冨田公夫(他9名), Kenji Ito]
通讯作者:
Kenji Ito
DOI:
10.1007/s10157-009-0195-1
发表时间:
2009-10-01
期刊:
CLINICAL AND EXPERIMENTAL NEPHROLOGY
影响因子:
2.3
作者:
[Ishimura, Atsunori, Watanabe, Maho, Saito, Takao]
通讯作者:
Saito, Takao
Macroage impairment produced by Fc receptor gamma deficiency plays a principal role in the development of lipoprotein glomerulopathy in concert with apoE abnormalities
Fc 受体 γ 缺乏引起的巨龄细胞损伤在脂蛋白肾小球病的发生中起主要作用,并与 apoE 异常相关
DOI:
--
发表时间:
2012
期刊:
Nephrol Dial Transplant
影响因子:
--
作者:
[Ito K, Nakashima H, Watanabe M., Ishimura A., Miyahara Y., Abe Y., Yasuno T., Ifuku M, Saito T.]
通讯作者:
Saito T.
Fc受容体γ鎖欠損がリポ蛋白糸球体症発症に影響する機序の検討
Fc受体γ链缺陷影响脂蛋白肾小球病发生的机制研究
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[伊藤建二、斉藤喬雄, 他]
通讯作者:
他
共 15 条
Legal Systems to Balance Grassland Landscape Preservation with Ger Camp Development in Mongolia and Inner Mongolia
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批准号:22402011
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$5.57万
-
财政年份:2010
-
负责人:SAITO Takao
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依托单位:
Development of a novel method for analyzing murine lipoprotein profile and application for an experimental model of lipoprotein glomerulopathy
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批准号:18590917
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.44万
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财政年份:2006
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负责人:SAITO Takao
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依托单位:
TCR-ζ EXPRESSION AND APOPTOSIS IN PERIPHRAL BLOOD MONONUCLEAR CELLS OF PATIENTS WITH HEAD AND NECK CANCER
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批准号:14571639
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2002
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负责人:SAITO Takao
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依托单位:
A STUDY ON SYNTHESIS OF HETEROCYCLES VIA CROSS-CONJUGATED HETEROTRIENES AND FUNCTIONALIZED CARBODIIMIDES AS KEY INTERMEDIATES
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批准号:14540504
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
-
财政年份:2002
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负责人:SAITO Takao
-
依托单位:
Analysis of glomerular lesions in an experimental model induced by apolipoprotein E gene.
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批准号:14571043
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
-
财政年份:2002
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负责人:SAITO Takao
-
依托单位:
A STUDY ON HETEROCYCLIC SYNTHESIS VIA CYCLIZATION AS A KEY REACTION FROM HETERO ATOM-CONTAINING UNSATURATED COMPOUNDS
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批准号:10640531
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$0.64万
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财政年份:1998
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负责人:SAITO Takao
-
依托单位:
Histochemical study for apolipoprotein abnormalities in lipoprotein glomerulopathy
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批准号:10670982
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.05万
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财政年份:1998
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负责人:SAITO Takao
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依托单位:
Histochemical and molecular-biological study on apoptosis in the model of renal failure
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批准号:07671231
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.47万
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财政年份:1995
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负责人:SAITO Takao
-
依托单位:
Effects of immunosuppresants on the activated-T cell infiltration mediating progression of glomerular lesions
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批准号:04670367
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1992
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负责人:SAITO Takao
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依托单位:
Etiology and treatment of postoperative severe infections based on impaired host defense systems in patients with digestive organ cancers
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批准号:01480329
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.35万
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财政年份:1989
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负责人:SAITO Takao
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依托单位:
Development of intensive breeding management technique and utilization of venison for Japanese deer as new meat resources
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批准号:62860034
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项目类别:Grant-in-Aid for Developmental Scientific Research
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资助金额:$1.73万
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财政年份:1987
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负责人:SAITO Takao
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依托单位:
Theoretical and Practical Studies on Accounting Measurement
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批准号:60301099
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项目类别:Grant-in-Aid for Co-operative Research (A)
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资助金额:$7.87万
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财政年份:1985
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负责人:SAITO Takao
-
依托单位:
A study on factors promoting the development of cancer in the remnant stomach.
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批准号:59480282
-
项目类别:Grant-in-Aid for Scientific Research (C).
-
资助金额:$4.54万
-
财政年份:1984
-
负责人:SAITO Takao
-
依托单位:
海外基金