Elucidation of the pathogenesis of visual halllucination in Parkinson's disease

阐明帕金森病幻视发病机制

• 批准号: 21591111
• 负责人: WATANABE Hirohisa
• 金额: $ 2.91万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591111/
• 关键词: パーキンソン病; 幻視; 認知機能検査; 視覚認知; 脳画像; 事象関連電位

The aim of this study was to elucidate the pathogenesis of visual hallucination(VH) in Parkinson's disease(PD). PD patients showed impairment of the visual perception especially in visual discrimination and figure ground. Voxel-based morphometry showed that PD patients with VH had widespread cortical atrophy including the occipital lobe and nucleus basalis of Meynert compared to normal control. Urinary 8-OHdG values significantly correlated with the score of TUHARS. It is assumed that VH is associated with the combination of functional decline in low-level visual cognition and functional impairment in the high-level visual cognition. In addition, oxidative stress may contribute to VH.

本研究的目的是阐明帕金森病（PD）视幻觉（VH）的发病机制。PD患者表现出视觉知觉障碍，尤其是视觉辨别和图形背景障碍。体素形态测量显示，与正常对照相比，伴有VH的PD患者有广泛的皮质萎缩，包括枕叶和Meynert基底核。尿8-OHdG值与TUHARS评分显著相关。我们认为VH与低水平视觉认知功能下降和高水平视觉认知功能障碍相结合。此外，氧化应激也可能导致VH。

项目成果

パーキンソン病における幻覚と脳萎縮の関係

帕金森病幻觉与脑萎缩的关系

• 发表时间: 2011
• 作者: 森秀一;久保幸穂;秋好沢諭;山田茂;宮崎剛;重本和宏;宮崎雄
• 通讯作者: 宮崎雄

Urinary 8-hydroxydeoxyguanosine correlate with hallucinations rather than motor symptoms in Parkinson's disease

• DOI: 10.1016/j.parkreldis.2010.11.004
• 发表时间: 2011-01-01
• 期刊: PARKINSONISM & RELATED DISORDERS
• 影响因子: 4.1
• 作者: Hirayama, Masaaki;Nakamura, Tomohiko;Sobue, Gen
• 通讯作者: Sobue, Gen

パーキンソン病における幻覚、認知、尿中8-OHdGと脳萎縮

帕金森病的幻觉、认知、尿 8-OHdG 和脑萎缩

• 发表时间: 2011
• 作者: 別宮豪一;隅寿恵;加藤信介;山寺みさき;佐古田三郎;平山正昭
• 通讯作者: 平山正昭

パーキンソン病における認知機能障害と脳MRI、脳血流障害の特徴

帕金森病认知功能障碍、脑MRI及脑血流障碍特点

• 发表时间: 2010
• 作者: 山寺みさき;隅寿恵;別宮豪一;藤村晴俊;加藤信介;佐古田三郎;新美芳樹
• 通讯作者: 新美芳樹

Widespread cortical and subcortical brain atrophy in Parkinson's disease with excessive daytime sleepiness

• DOI: 10.1007/s00415-011-6187-6
• 发表时间: 2012-02-01
• 期刊: JOURNAL OF NEUROLOGY
• 影响因子: 6
• 作者: Kato, S.;Watanabe, H.;Sobue, G.
• 通讯作者: Sobue, G.