Effects of the anticholinesterase drug to motor end-plates in myasthenia gravis and changes of the protein which constitutes motor end plate

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We examined fine structural changes in motor end plates which anticholinesterase affected in rats with human anti-MuSK or anti-Acethylcholine receptor(AChR) antibodies. The results can usually use anticholinesterase of the consumption in MG with anti-MuSK autoantibody. We also studied the morphological changes in the MG patients with anti-LRP4, anti-MuSK autoantibody or anti-AChR antibodies as the causative autoantibody of MG, An anti-LRP4 antibody and the anti-MuSK autoantibody induce a same change in motor end plate. The motor end plates in the ColQ defect mouse appeared like a change at the time of the anticholinesterase drug overdosage.