Role of TFAP2B as environment response gene on Metabolic Syndrome

TFAP2B 作为环境反应基因在代谢综合征中的作用

• 批准号: 21591129
• 负责人: MAEGAWA Hiroshi
• 金额: $ 2.91万
• 依托单位: Shiga University of Medical Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591129/
• 关键词: メタボリックシンドローム; 肥満; 脂肪組織; 転写因子; AP2B; アディポサイトカイン; 遺伝子改変マウス; AP-2β; PKCμ; MCP-1; Adiponectin; IL-6; TNFα; アディポネクチン; レプチン; 皮下脂肪組織; 内臓脂肪組織; TFAP2B

TFAP2B(AP-2β) is a candidate gene for conferring susceptibility to obesity and type 2 diabetes. We also found that protein kinase C(PKC)μwas highly phosphorylated in the re-feeding condition. Furthermore, overexpression of PKCμenhanced the effects of AP-2βon the expression of these adipocytokines. We also found that overexpression of AP-2βin 3T3-L1 adiposities impaired the promoter activity of IRS-1, and subsequently decreased mRNA and protein expression. Theses findings suggested that postprandial activation of PKCμplays roles in disordered postprandial adipocytokine expression and impaired insulin signaling through AP-2β.

TFAP 2B（AP-2β）是肥胖和2型糖尿病易感性的候选基因。我们还发现，蛋白激酶C（PKC）μ在再喂养条件下高度磷酸化。此外，PKCμ过表达增强AP-2β对这些脂肪细胞因子表达的影响。我们还发现，AP-2β在3 T3-L1肥胖中的过表达损害了IRS-1的启动子活性，随后降低了mRNA和蛋白表达。提示餐后激活PKCμ参与了餐后脂肪细胞因子表达紊乱和AP-2β介导的胰岛素信号转导受损。

项目成果

Relation of the Expression of Transcriptional Factor TFAP2B to That of Adipokines in Subcutaneous and Omental Adipose Tissues

• DOI: 10.1038/oby.2009.442
• 发表时间: 2010-07-01
• 期刊: OBESITY
• 影响因子: 6.9
• 作者: Ugi, Satoshi;Nishio, Yoshihiko;Maegawa, Hiroshi
• 通讯作者: Maegawa, Hiroshi

Transcription factor AP-2β inhibits expression and secretion of leptin, an insulin-sensitizing hormone, in 3T3-L1 adipocytes

• DOI: 10.1038/ijo.2009.295
• 发表时间: 2010-04-01
• 期刊: INTERNATIONAL JOURNAL OF OBESITY
• 影响因子: 4.9
• 作者: Fuke, T.;Yoshizaki, T.;Maegawa, H.
• 通讯作者: Maegawa, H.

Autophagy regulates inflammation in adipocytes.

• DOI: 10.1016/j.bbrc.2011.11.114
• 发表时间: 2012-01
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: Takeshi Yoshizaki;Chisato Kusunoki;Motoyuki Kondo;M. Yasuda;S. Kume;K. Morino;Osamu Sekine;S. Ugi;T. Uzu;Y. Nishio;A. Kashiwagi;H. Maegawa

Association between serum soluble TNFα receptors and renal dysfunction in type 2 diabetic patients without proteinuria

• DOI: 10.1016/j.diabres.2011.01.008
• 发表时间: 2011-05-01
• 期刊: DIABETES RESEARCH AND CLINICAL PRACTICE
• 影响因子: 5.1
• 作者: Miyazawa, Itsuko;Araki, Shin-ichi;Maegawa, Hiroshi
• 通讯作者: Maegawa, Hiroshi

Possible role of transcriptional factor TFAP2B in regulation of adipokine genes in subcutaneous and omental adipose tissues

转录因子 TFAP2B 在皮下和网膜脂肪组织脂肪因子基因调节中的可能作用

• 发表时间: 2010
• 期刊: Obesity (In press)
• 作者: Ugi S;Maegawa H;et al
• 通讯作者: et al