Influence of bone related cells on leukemic cells

骨相关细胞对白血病细胞的影响

• 批准号: 21591201
• 负责人: KIMURA Shinya
• 金额: $ 2.83万
• 依托单位: Saga University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591201/
• 关键词: 白血病; 骨; ニッチ; 骨芽細胞; 破骨細胞; 慢性骨髄性白血病; ナノチャンバー; ABLチロシンキナーゼ

We have established co-culture system with osteoblasts, osteoclasts, bones and leukemic cells to investigate the influence of bone related cells on leukemic cells. With this system, we found that osteoblasts stimulated the proliferation of leukemic cells, and leukemic cells which were introduced to quiescent phase by TGF-・that was released from bone via osteoclasts acquired the resistance to ABL tyrosine kinase inhibitors.

我们建立了成骨细胞、破骨细胞、骨与白血病细胞共培养体系，研究骨相关细胞对白血病细胞的影响。在此系统中，我们发现成骨细胞刺激白血病细胞增殖，并且通过破骨细胞从骨中释放的TGF-·将白血病细胞引入静止期，使白血病细胞获得对ABL酪氨酸激酶抑制剂的抗性。

项目成果

A fully integrated and automated detection system for single nucleotide polymorphisms of UGT1A1 and CYP2C19

UGT1A1 和 CYP2C19 单核苷酸多态性的完全集成自动化检测系统

• 发表时间: 2011
• 期刊: Oncol Res
• 影响因子: 3.1
• 作者: Ureshino N;Aragane N;Nakamura T;Ide M;Mochinaga S;Fukushima N;Hayashi S;Sueoka E;Kimura S
• 通讯作者: Kimura S

Wada. Monitoring with a non-invasive bioluminescent in vivo imaging system of successful treatment of disseminated pleural tumors by intra-pleural docetaxel administration

和田。

• 发表时间: 2009
• 期刊: Lung Cancer
• 影响因子: 5.3
• 作者: Matsumoto S;Tanaka F;Sato K;Kimura S;Maekawa T;Hasegawa S
• 通讯作者: Hasegawa S

Intravesical administration of・・T cells successfully prevents the growth of bladder cancer in the murine model

膀胱内注射 T 细胞成功阻止小鼠模型中膀胱癌的生长

• 发表时间: 2009
• 期刊: Cancer Immunol Immun
• 影响因子: 5.8
• 作者: Yuasa T;Sato K;Ashihara E;Takeuchi M;Maita S;Tsuchiya N;Habuchi T;Maekawa T;Kimura S.
• 通讯作者: Kimura S.

Growth inhibition of imatinib-resistant CML cells with the T315I mutation and hypoxia adaptation by AV65, a novel Wnt/β-catenin signaling inhibitor

新型 Wnt/β-catenin 信号抑制剂 AV65 对 T315I 突变和缺氧适应的伊马替尼耐药 CML 细胞的生长抑制

• 发表时间: 2011
• 期刊: Cancer Lett
• 影响因子: 9.7
• 作者: Nagao R;Ashihara E;Kimura S;Strovel JW;Yao H;Takeuchi M;Tanaka R;Hayashi Y;Hirai H;Padia J;Strand K;Maekawa T.
• 通讯作者: Maekawa T.

Clinically relevant dose of zoledronic acid inhibits spontaneous lung metastasis in a murine osteosarcoma model

• DOI: 10.1016/j.canlet.2008.09.026
• 发表时间: 2009-02-18
• 期刊: CANCER LETTERS
• 影响因子: 9.7
• 作者: Koto, Kazutaka;Horie, Naoyuki;Kubo, Toshikazu
• 通讯作者: Kubo, Toshikazu