Association of linkage between autoantigens and, ubiquitin. proteasome system in autoantibody production

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We studied immune response to components of proteasome using sera from patients with various connective tissue diseases by immunoblotting. Then, we found that there is a linkage of autoimmune response among components of proteasome and their binding proteins. In addition, We found that circulating proteasome detected by sandwich type ELISA is significantly associated with autoimmune response to proteasome and its binding proteins. These results suggested that the circulating ubiquitin-proteasome complex binding with autoantigens in association with its biologic function is playing an important role to induce autoimmune response to its binding antigens.