Analysis of collagen-induced arthritis and bacterial colitis using Cas-L null mice

使用 Cas-L 缺失小鼠分析胶原诱导的关节炎和细菌性结肠炎

• 批准号: 21591278
• 负责人: IWATA Satoshi
• 金额: $ 2.91万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591278/
• 关键词: インテグリン; シトロバクター; 病原性大腸菌; コラーゲン関節炎; Nedd9; HEF-1; 接着分子; コラーゲン誘発関節炎; 感染性大腸炎; Cas; 関節リウマチ; 骨粗鬆症; 免疫学

Crk-associated substrate lymphocyte type(Cas-L) is an integrin signaling adaptor protein composed of multiple domains serving as a substrate for a variety of tyrosine kinases. Cas-L functions in diverse biological processes such as cell attachment, migration and invasion, apoptosis, and cell cycle progression. To elucidate the function of Cas-L in autoimmune diseases and host defence, we employed Cas-L knockout mice. It was shown that these mice relatively resistant to collagen-induced arthritis, on the other hands, they were susceptible to Citrobacter rodentium infection of colon.

Crk相关底物淋巴细胞型（Cas-L）是一种由多个结构域组成的整合素信号转导衔接蛋白，作为多种酪氨酸激酶的底物。Cas-L在多种生物学过程中发挥作用，例如细胞附着、迁移和侵袭、凋亡和细胞周期进程。为了阐明Cas-L在自身免疫性疾病和宿主防御中的功能，我们采用Cas-L敲除小鼠。结果表明，这些小鼠对胶原诱导的关节炎具有相对抵抗力，另一方面，它们对结肠的柠檬酸杆菌感染易感。

项目成果

CD9 correlates with cancer stem cell potentials in human B-acute lymphoblastic leukemia cells

• DOI: 10.1016/j.bbrc.2009.02.123
• 发表时间: 2009-04-24
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Nishida, Hiroko;Yamazaki, Hiroto;Morimoto, Chikao
• 通讯作者: Morimoto, Chikao

Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects

• DOI: 10.1016/j.jep.2009.11.024
• 发表时间: 2010-02-17
• 期刊: JOURNAL OF ETHNOPHARMACOLOGY
• 影响因子: 5.4
• 作者: Otsuki, Noriko;Dang, Nam H.;Morimoto, Chikao
• 通讯作者: Morimoto, Chikao

The CD70-CD27 interaction during the stimulation with dendritic cells promotes naive CD4+ T cells to develop into T cells producing a broad array of immunostimulatory cytokines in humans

• DOI: 10.1093/intimm/dxp056
• 发表时间: 2009-08-01
• 期刊: INTERNATIONAL IMMUNOLOGY
• 影响因子: 4.4
• 作者: Hashimoto-Okada, Mutsumi;Kitawaki, Toshio;Uchiyama, Takashi
• 通讯作者: Uchiyama, Takashi

Optimal stimulation for CD70 induction on human monocyte-derived dendritic cells and the importance of CD70 in naive CD4+T-cell differentiation

• DOI: 10.1111/j.1365-2567.2010.03220.x
• 发表时间: 2010-05-01
• 期刊: IMMUNOLOGY
• 影响因子: 6.4
• 作者: Arimoto-Miyamoto, Kazue;Kadowaki, Norimitsu;Uchiyama, Takashi
• 通讯作者: Uchiyama, Takashi

Cas-L/Nedd 9ノックアウトマウスを用いた関節炎の解析

使用 Cas-L/Nedd 9 敲除小鼠分析关节炎

• 发表时间: 2010
• 作者: Hayashi M;Koya T;Kawakami H;Sakagami T;Hasegawa T;Kagamu H;Takada T;Sakai Y;Suzuki E;Gelfand EW;Gejyo F;片寄智規 岩田哲史 村上聡 吉川理子 細野治 河崎寛 金井芳之 田中廣壽 森本幾夫
• 通讯作者: 片寄智規 岩田哲史 村上聡 吉川理子 細野治 河崎寛 金井芳之 田中廣壽 森本幾夫